N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents

ABSTRACT

Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted phenyl group, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and antiinflammatory agents in mammalian subjects. These 2-oxindole-1-carboxamide compounds are of particular value for ameliorating pain in human patients recovering from surgery or trauma, and alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects. 
     Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having a substituent on the carboxamide nitrogen, are useful as intermediates to the analgesic and antiinflammatory agents of the invention.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation-in-part of application Ser. No. 607,356, filed May 4, 1984, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to new chemical compounds. More particularly, these new chemical compounds are derivatives of 2-oxindole-1-carboxamide, and they are further substituted at the 3-position by an acyl group, and on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl, substituted phenyl or heterocyclic group. These new chemical compounds are inhibitors of both the cyclooxygenase (CO) and lipoxygenase (LO) enzymes.

The compounds of this invention possess analgesic activity in mammals, particularly man, and they are useful therefore for acute administration for ameliorating or eliminating pain, such as the pain experienced by patients recovering from surgery or trauma.

In addition to their usefulness for acute administration to combat pain, the compounds of this invention are useful for chronic administration to mammals, particularly man, to alleviate the symptoms of chronic diseases, such as the inflammation and pain associated with rheumatoid arthritis and osteoarthritis.

SUMMARY OF THE INVENTION

This invention provides novel 2-oxindole-1-carboxamide compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof; wherein

X is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons, trifluoromethyl, alkylsulfinyl having 1 to 4 carbons, alkylsulfonyl having 1 to 4 carbons, nitro, phenyl, alkanoyl having 2 to 4 carbons, benzoyl, thenoyl, alkanamido having 2 to 4 carbons, benzamido and N,N-dialkylsulfamoyl having 1 to 3 carbons in each of said alkyls; and Y is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons and trifluoromethyl;

or X and Y when taken together are a 4,5-, 5,6- or 6,7-methylenedioxy group or a 4,5-, 5,6- or 6,7-ethylenedioxy group;

or X and Y when taken together and when attached to adjacent carbon atoms, form a divalent radical Z, wherein Z is selected from the group consisting of ##STR2## wherein W is oxygen or sulfur;

R¹ is selected from the group consisting of alkyl having 1 to 6 carbons, cycloalkyl having 3 to 7 carbons, cycloalkenyl having 4 to 7 carbons, phenyl, substituted phenyl, phenylalkyl having 1 to 3 carbons in said alkyl, (substituted phenyl)alkyl having 1 to 3 carbons in said alkyl, phenoxyalkyl having 1 to 3 carbons in said alkyl, (substituted phenoxy)alkyl having 1 to 3 carbons in said alkyl, (thiophenoxy)alkyl having 1 to 3 carbons in said alkyl, naphthyl, bicyclo[2.2.1]heptan-2-yl, bicyclo[2.2.1]hept-5-en-2-yl and --(CH₂)_(n) --Q--R°;

wherein the substituent on said substituted phenyl, said (substituted phenyl)alkyl and said (substituted phenoxy)alkyl is selected from the group consisting of fluoro, chloro, bromo, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl; n is zero, 1 or 2; Q is a divalent radical derived from a compound selected from the group consisting of furan, thiophene, pyrrole, pyrazole, imidazole, thiazole, isothiazole, oxazole, isoxazole, 1,2,3-thiadiazole, 1,3,4-thiadiazole, 1,2,5-thiadiazole, tetrahydrofuran, tetrahydrothiophene, tetrahydropyran, tetrahydrothiopyran, pyridine, pyrimidine, pyrazine, benzo[b]furan and benzo[b]thiophene; and R° is hydrogen or alkyl having 1 to 3 carbons;

and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl and a group of the formula ##STR3## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.

Said compounds of formula I are active as analgesic agents, and as agents for treating inflammatory diseases, such as the arthritides. Accordingly, this invention also provides a method of eliciting an analgesic response in a mammalian subject, especially man; a method of treating an inflammatory disease in a mammalian subject, especially man; and pharmaceutical compositions comprising a compound of formula I and a pharmaceutically-acceptable carrier.

A preferred group of compounds of this invention consists of the compounds of formula I, wherein X and Y are each selected from the group consisting of hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl and 6-trifluoromethyl, and R¹ and R² are as previously defined. Within this preferred group, particularly preferred compounds are those wherein R¹ is selected from the group consisting of benzyl, 2-furyl, 2-thienyl, (2-furyl)methyl and (2-thienyl)methyl.

Especially preferred individual compounds of this invention are:

N-t-butyl-5-chloro-3-(2-furoyl)-2-oxindole-1-carboxamide (I: X is 5-chloro; Y is hydrogen; R¹ is 2-furyl; R² is t-butyl);

N-t-butyl-5-fluoro-3-(2-furoyl)-2-oxindole-1-carboxamide (I: X is 5-fluoro; Y is hydrogen; R¹ is 2-furyl; R² is t-butyl);

N-t-butyl-6-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide (I: X is 6-chloro; Y is hydrogen; R¹ is 2-thienyl; R² is t-butyl);

N-(4-methoxyphenyl)-3-(2-thenoyl)-2-oxindole-1-carboxamide (I: X is hydrogen; Y is hydrogen; R¹ is 2-thienyl; R² is 4-methoxyphenyl); and

N-(2,4-difluorophenyl)-3-(2-furoyl)-2-oxindole-1-carboxamide (I: X is hydrogen; Y is hydrogen; R¹ is 2-furyl; R² is 2,4-difluorophenyl).

Useful as intermediates to the compounds of the formula I are the compounds of the formula ##STR4## wherein X, Y and R² are as defined previously. A valuable sub-group of compounds of the formula V consists of those compounds in which X and Y are each selected from the group consisting of hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl and 6-trifluoromethyl, provided that X and Y are not both hydrogen. The compounds of formula V in said latter sub-group are novel, and as such they form part of this invention.

DETAILED DESCRIPTION OF THE INVENTION

This invention relates to the compounds of formula I, and these compounds are named as derivatives of 2-oxindole, the compound of formula II: ##STR5## More particularly, the analgesic and antiinflammatory agents of formula I have a carboxamide substituent, --C(═O)--NH--R², at the 1-position and an acyl substituent, --C(═O)--R¹, at the 3-position of 2-oxindole, and the benzo ring can be further substituted by X and Y groups. X and Y can be certain monovalent substituents as defined previously, or X and Y when on adjacent carbon atoms on the benzo ring can represent a methylenedioxy group, --OCH₂ O--, or an ethylenedioxy group, --OCH₂ CH₂ O--. Yet further, X and Y, when they are attached to adjacent carbon atoms of the benzo ring of the 2-oxindole, can form a divalent unit, Z, such that when Z is taken with the carbon atoms to which it is attached it forms a fused carbocyclic or heterocyclic ring. Certain divalent groups for Z (i.e. Z¹ -Z⁵) have been listed earlier. Thus, when Z is Z¹, X and Y when taken with the carbons to which they are attached represent a fused cyclopentene ring; and when Z is Z⁵, X and Y when taken with the carbons to which they are attached represent a fused furan or thiophene ring. Moreover, it is to be understood that when Z is Z⁴ or Z⁵, the Z group can be attached in either of two possible ways. Thus, for example, when X and Y are at C-5 and C-6 and they are Z⁵, the formula I embraces both of the following formulae: ##STR6##

Additionally, as will be appreciated by one skilled in the art, the analgesic and anti-inflammatory compounds of this invention of formula I, wherein X, Y, R¹ and R² are defined previously, are capable of enolization, and therefore they can exist in one or more tautomeric (enolic) forms. All such tautomeric (enolic) forms of the compounds of formula I are considered to be within the scope of this invention.

The compounds of the formula I are prepared from the appropriate 2-oxindole compound of the formula III: ##STR7## wherein X and Y are as defined previously. This is accomplished by attaching the substituent --C(═O)--NH--R² to the 1-position and the --C(═O)--R¹ substituent to the 3-position. These substituents can be attached in either order, and this leads to two variations in the method for making the compounds of formula I, as shown in the Scheme. ##STR8##

Thus the first variation involves the sequence: compound III to compound IV to compound I; the second variation involves the sequence: compound III to compound V to compound I.

The --C(═O)--NH--R² group can be attached by reacting a compound of the formula III or a compound of the formula IV with an isocyanate of the formula R² --N═C═O. Most commonly, the reaction is carried out by contacting substantially equimolar quantities of the reactants in an inert solvent at a temperature in the range from 50° C. to 150° C., and preferably from 100° to 130° C. In this context an inert solvent is one which will dissolve at least one of the reactants, and which does not adversely interact with either of the reactants or the product. Typical solvents which can be used include aliphatic hydrocarbons, such as octane, nonane, decane and decalin; aromatic hydrocarbons, such as benzene, chlorobenzene, toluene, xylenes and tetralin; chlorinated hydrocarbons, such as 1,2-dichloroethane; ethers, such as tetrahydrofuran, dioxane, 1,2-dimethoxyethane and di(2-methoxyethyl) ether; and polar, aprotic solvents such as N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidone and dimethyl sulfoxide. The reaction time varies according to the reaction temperature, but at a temperature from 100° to 130 ° C., reaction times of a few hours, e.g., 5 to 10 hours are commonly used.

When a relatively non-polar reaction solvent is used for the reaction of a compound of formula III or IV with an isocyanate of formula R² --N═C═O, the product (V or I) is usually out of solution at the end of the reaction when the reaction mixture is cooled to room temperature. Under these circumstances the product is usually recovered by filtration. However, if relatively polar solvents are used and the product is not out of solution at the end of the reaction, the product can be recovered by solvent evaporation. Alternatively, in the case of water-miscible solvents, dilution of the reaction medium with water causes the product to precipitate, and again it can be recovered by filtration. The reaction product (I or V) can be purified by standard methods, e.g., recrystallization.

The reaction between a compound of formula IV and an isocyanate of formula R² --N═C═O can be speeded up by the addition of a base, such as a tertiary amine, e.g., trimethylamine, triethylamine, tributylamine, N-methylpiperidine, N-methylmorpholine or N,N-dimethylaniline. From about one to about four equivalents of the basic agent are usually added, and this permits the use of reaction temperature from 20 to 50° C. At the end of the reaction, the reaction medium must be neutralized (or made acidic) and then the product is isolated as described earlier.

The --C(═O)--R¹ side-chain can be attached to a compound of the formula V by reaction with one molar equivalent or a slight excess of an activated derivative of a carboxylic acid of the formula R¹ --C(═O)OH, in the presence of from one to four equivalents of a basic agent. An inert solvent is one which will dissolve at least one of the reactants, and will not adversely interact with either of the reactants or the product. However, in practice a polar, aprotic solvent, such as N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidone or dimethyl sulfoxide, is commonly used. Conventional methods for activating the acid of formula R^(1--C)(═O)OH are used. For example, acid halides, e.g., acid chlorides; symmetrical acid anhydrides, R¹ --C(═O)--O--C(═O)--R¹ ; mixed acid anhydrides with a hindered low-molecular weight carboxylic acid, R¹ --C(═O)--O--C(═O)--R⁵, where R⁵ is a bulky lower-alkyl group such as t-butyl; and mixed carboxylic-carbonic anhydrides, R¹ --C(═O)--O--C(═O)--OR⁶, wherein R⁶ is a lower alkyl group, can all be used. In addition, N-hydroxyimide esters (such as N-hydroxysuccinimide and N-hydroxyphthalimide esters), 4-nitrophenyl esters, thiol esters (such as thiol phenyl esters) and 2,4,5-trichlorophenyl esters, and the like, can be used.

A wide variety of basic agents can be used in the reaction between a compound of formula V and the activated derivative of the acid of the formula R¹ --C(═O)OH However, preferred basic agents are tertiary amines, such as trimethylamine, triethylamine, tributylamine, N-methylmorpholine, N-methylpiperidine and 4-(N,N-dimethylamino)pyridine.

The reaction between a compound of the formula V and the activated derivative of the acid of formula R¹ --C(═O)--OH is usually carried out in the temperature range from -10° to 25° C. Reaction times of from 30 minutes to a few hours are common. At the end of the reaction, the reaction medium is usually diluted with water and acidified, and then the product can be recovered by filtration. It can be purified by standard methods, such as recrystallization.

The --C(═O)--R¹ side-chain can be attached to a compound of the formula III by reaction with a derivative of the appropriate acid of the formula R¹ --C(═O)--OH, in a lower-alkanol solvent (e.g. ethanol), in the presence of an alkali metal salt of the lower-alkanol solvent (e.g. sodium ethoxide), according to standard procedures. Typical derivatives of the acid of the formula R¹ --C(═O)OH which can be used include acid chlorides, acid anhydrides of the formula R¹ --C(═O)--O--C(═O)--R¹, R¹ --C(═O)--O--C(═O)--R⁵ and R¹ --C(═O)--O--C(═O)--OR⁶, and simple alkyl esters of the formula R¹ --C(═O)--OR⁶ ; wherein R⁵ and R⁶ are as defined previously. Usually, a small excess of the derivative of the acid of formula R¹ --C(═O)--OH is used, and the alkoxide salt is usually present in an amount from one to two molar equivalents, based on said derivative of the acid of formula R¹ --C(═O)OH. The reaction between the derivative of the acid of the formula R¹ --C(═O)OH and the compound of formula III is usually started at 0° to 25° C., but it is then usual to heat the reaction mixture at a temperature in the range from 50° to 130° C., and preferably at about 80° C., to complete the reaction. Under these circumstances, reaction times of a few hours, e.g. two hours, up to a few days, e.g., two days, are commonly used. The reaction mixture is then cooled, diluted with an excess of water, and acidified. The product of formula IV can then be recovered by filtration or by the standard procedure of solvent extraction.

The isocyanates of the formula R² --N═C═O can be prepared by standard procedures. See further: "Organic Functional Group Preparations" by Sandler and Karo, Part I, Second Edition, Academic Press, Inc., New York, N.Y., 1983, Chapter 12, pp. 364-369. A particularly useful method involves reaction of the appropriate amine of formula R² --NH₂ with phosgene:

    R.sup.2 --NH.sub.2 +COCl.sub.2 →R.sup.2 --N═C═O+2HCl

Many of the isocyanates of formula R² --N═C═O are known in the prior art.

The 2-oxindole compounds of formula III are prepared by known methods, or methods analogous to known methods. Consult: "Rodd's Chemistry of Carbon Compounds," Second Edition, S. Coffey editor, Volume IV Part A, Elsevier Scientific Publishing Company, 1973, pp. 448-450; Gassman et al., Journal of Organic Chemistry, 42, 1340 (1977); Wright et al., Journal of the American Chemical Society, 78, 221 (1956); Beckett et al., Tetrahedron, 24, 6093 (1968); U.S. Pat. Nos. 3,882,236, 4,006,161 and 4,160,032; Walker, Journal of the American Chemical Society, 77, 3844 (1955); Protiva et al., Collection of Czechoslovakian Chemical Communications, 44, 2108 (1979); McEvoy et al., Journal of Organic Chemistry, 38, 3350 (1973); Simet, Journal of Organic Chemistry, 28, 3580 (1963); Wieland et al., Chemische Berichte, 96, 253 (1963); and references cited therein.

The compounds of the formula I are acidic and they form base salts. All such base salts are within the scope of this invention and they can be prepared by conventional methods. For example, they can be prepared simply by contacting the acidic and basic entities, usually in a stoichiometric ratio, in either an aqueous, non-aqueous or partially aqueous medium, as appropriate. The salts are recovered either by filtration, by precipitation with a non-solvent followed by filtration, by evaporation of the solvent, as appropriate, or, in the case of aqueous solutions, by lyophilization. Typical salts of the compounds of formula I which can be prepared are primary, secondary and tertiary amine salts, alkali metal salts and alkaline earth metal salts. Especially valuable are the ethanolamine, diethanolamine and triethanolamine salts.

Basic agents suitably employed in salt formation belong to both the organic and inorganic types, and they include organic amines, alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates, alkali metal hydrides, alkali metal alkoxides, alkaline earth metal hydroxides, alkaline earth metal carbonates, alkaline earth metal hydrides and alkaline earth metal alkoxides. Representative examples of such bases are primary amines, such as n-propylamine, n-butylamine, aniline, cyclohexylamine, benzylamine, p-toluidine, ethanolamine and glucamine; secondary amines, such as diethylamine, diethanolamine, N-methylglucamine, N-methylaniline, morpholine, pyrrolidine and piperidine; tertiary amines, such as triethylamine, triethanolamine, N,N-dimethylaniline, N-ethylpiperidine and N-methylmorpholine; hydroxides, such as sodium hydroxide; alkoxides, such as sodium ethoxide and potassium methoxide; hydrides, such as calcium hydride and sodium hydride; and carbonates, such as potassium carbonate and sodium carbonate.

The compounds of formula I possess analgesic activity. This activity has been demonstrated in mice by showing blockade of the abdominal stretching induced by administration of 2-phenyl-1,4-benzoquinone (PBQ). The method used was based on that of Siegmund et al., Proc. Soc. Exp. Biol. Med., 95, 729-731, (1957), as adapted for high throughput (see further Milne and Twomey, Agents and Actions, 10, 31-37, [1980]). The mice used in these experiments were Carworth males, albino CF-1 strain, weighing 18-20 g. All mice were fasted overnight prior to drug administration and testing.

The compounds of formula I were dissolved or suspended in a vehicle consisting of ethanol (5%), emulphor 620 (a mixture of polyoxyethylene fatty acid esters, 5%) and saline (90%). This vehicle also served as control. Doses were on a logarithmic scale (i.e., . . . 0.32, 1.0, 3.2, 10, 32 . . . mg/kg). The route of administration was oral, with concentrations varied to allow a constant dosage volume of 10 ml/kg of body weight. The aforesaid method of Milne and Twomey was used to determine efficacy and potency. Mice were treated with compounds orally, and one hour later received PBQ, 2 mg/kg, intraperitoneally. Individual mice were then immediately placed in a warmed lucite chamber, and, starting five minutes after PBQ administration, the number of abdominal constrictions during the subsequent 5 minutes was recorded. The degree of analgesic protection (% MPE) was calculated on the basis of suppression of abdominal constriction relative to counts from concurrent control animals run on the same day. At least four such determinations (N≧5) provided dose-response data for generation of an MPE₅₀, the best estimate of the dose that reduces abdominal constriction to 50% of control levels.

The compounds of formula I also possess anti-inflammatory activity. This activity has been demonstrated in rats by a method based on the standard carrageenin-induced rat-foot edema test. (Winter et al., Proc. Soc. Exp. Biol. Med., 111, 544, [1963]).

Unanesthetized, adult, male, albino rats of 150 g to 190 g body weight were numbered, weighed, and an ink mark placed on the right lateral malleolus. Each paw was immersed in mercury exactly to the ink mark. The mercury was contained in a glass cylinder, connected to a Statham Pressure Transducer. The output from the transducer was fed through a control unit to a microvoltameter. The volume of mercury displaced by the immersed paw was read. Drugs were given by gavage. One hour after drug administration, edema was induced by injection of 0.05 ml of 1% solution of carrageenin into the plantar tissue of the marked paws. Immediately thereafter, the volume of the injected foot was measured. The increase in foot volume 3 hours after the injection of carrageenin constitutes the individual inflammatory response.

The analgesic activity of the compounds of formula I makes them useful for acute administration to mammals for the control of pain, e.g., post-operative pain and the pain of trauma. Additionally the compounds of formula I are useful for chronic administration to mammals for the alleviation of the symptoms of chronic diseases, such as the inflammation of rheumatoid arthritis, and the pain associated with osteoarthritis and other musculoskeletal disorders.

When a compound of the formula I or a pharmaceutically acceptable salt thereof is to be used as either an analgesic agent or an anti-inflammatory agent, it can be administered to a mammalian subject either alone, or, preferably, in combination with pharmaceutically-acceptable carriers or diluents in a pharmaceutical composition, according to standard pharmaceutical practice. A compound can be administered orally or parenterally. Parenteral administration includes intravenous, intramuscular, intraperitoneal, subcutaneous and topical administration.

In a pharmaceutical composition comprising a compound of formula I, or a pharmaceutically-acceptable salt thereof, the weight ratio of carrier to active ingredient will normally be in the range from 1:4 to 4:1, and preferably 1:2 to 2:1. However, in any given case, the ratio chosen will depend on such factors as the solubility of the active component, the dosage contemplated and the precise route of administration.

For oral use of a compound of formula I of this invention, the compound can be administered, for example, in the form of tablets or capsules, or as an aqueous solution or suspension. In the case of tablets for oral use, carriers which are commonly used include lactose and corn starch, and lubricating agents, such as magnesium stearate, are commonly added. For oral administration in capsule form, useful diluents are lactose and dried corn starch. When aqueous suspensions are required for oral use, the active ingredient is combined with emulsifiying and suspending agents. If desired, certain sweetening and/or flavoring agents can be added. For intramuscular, intraperitoneal, subcutaneous and intravenous use, sterile solutions of the active ingredient are usually prepared, and the pH of the solutions should be suitably adjusted and buffered. For intravenous use, the total concentration of solutes should be controlled to render the preparation isotonic.

When a compound of formula I or salt thereof is used in a human subject, the daily dosage will normally be determined by the prescribing physician. Moreover, the dosage will vary according to the age, weight and response of the individual patient, as well as the severity of the patient's symptoms and the potency of the particular compound being administered. However, for acute administration to relieve pain, an effective analgesic response eliciting dose in most instances will be 0.02 to 0.5 g as needed (e.g., every four to twenty-four hours). For chronic administration to alleviate (treat) inflammation and pain, in most instances an effective dose will be from 0.02 to 1.0 g per day, and preferably 0.05 to 0.5 g per day, in single or divided doses. On the other hand, it may be necessary to use dosages outside these limits in some cases.

The following examples and preparations are being provided solely for the purpose of further illustration.

EXAMPLE 1 N-Phenyl-3-acetyl-2-oxindole-1-carboxamide

To a stirred slurry of 526 mg (3.0 mmole) of 3-cetyl-2-oxindole in 6 ml of toluene was added 393 mg (3.3 mmole) of phenyl isocyanate, and then the mixture was heated under reflux for 7 hours. The reaction mixture was cooled to room temperature and the precipitate was collected by filtration. The solid thus obtained was recrystallized from ca. 20 ml of acetonitrile to give 229 mg of the title compound as off-white needles, mp 171°-173° C.

Analysis: Calcd. for C₁₇ H₁₄ N₂ O₃ : C, 69,38; H, 4.79; N, 9.52%. Found: C, 69.31; H, 4.97; N, 9.59%.

EXAMPLE 2 N-t-Butyl-6-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide

A solution of 667 mg (2.5 mmole) of N-t-butyl-6-chloro-2-oxindole-1-carboxamide and 684 mg (5.6 mmole) of 4-(N,N-dimethylamino)pyridine in 8 ml of N,N-dimethylformamide was cooled in an ice-bath, and then a solution of 410 mg (2.8 mmole) of 2-thenoyl chloride in 2 ml of N,N-dimethylformamide was added dropwise, with stirring. Stirring was continued for ca. 30 minutes, and then the reaction mixture was poured into a mixture of 60 ml of water and 2.5 ml of 3N hydrochloric acid. The resulting mixture was cooled in an ice-bath, and then the solid was recovered by filtration and recrystallized from ca. 30 ml of acetic acid. This afforded 425 mg of the title compound as yellow crystals, mp 160.5°-161.5° C. (slight decomposition).

Analysis: Calcd. for C₁₈ H₁₇ ClN₂ O₃ S: C, 57.36; H, 4.55; N, 7.43%. Found: C, 57.29; H, 4.48; N, 7.38%.

EXAMPLE 3 N-(4-Fluorophenyl)-3-acetyl-2-oxindole-1-carboxamide

To a stirred slurry of 811 mg (3.0 mmole) of N-(4-fluorophenyl)-2-oxindole-1-carboxamide in 4 ml of N,N-dimethylformamide was added 806 mg (6.6 mmole) of 4-(N,N-dimethylamino)pyridine. Stirring was continued for a few minutes, and then the slurry was cooled in an ice-bath and a solution of 337 mg (3.3 mmole) of acetic anhydride in 2 ml of N,N-dimethylformamide was added. Stirring was continued for 1 hour, and then the reaction mixture was poured onto a mixture of 60 ml of ice-water and 2.2 ml of 3N hydrochloric acid. The solid which precipitated was recovered by filtration. It was recrystallized from acetonitrile to give 600 mg of the title compound as dark crystals, mp 181°-182° C.

Analysis: Calcd. for C₁₇ H₁₃ FN₂ O₃ : C, 65.38; H, 4.19; N, 8.97%. Found: C, 65.44; H, 4.31; N, 8.97%.

EXAMPLE 4 N-(2,4-Difluorophenyl)-3-(2-furoyl)-2-oxindole-1-carboxamide

To a stirred solution of 682 mg (3.0 mmole) of 3-(2-furoyl)-2-oxindole in 8 ml of dimethyl sulfoxide was added 668 mg (6.6 mmole) of triethylamine followed by 512 mg (3.3 mmole) of 2,4-difluorophenyl isocyanate. Stirring was continued for 1 hour, and then the reaction mixture was poured into 60 ml of water. The resulting mixture was acidified with 3N hydrochloric acid and then it was cooled in an ice-bath. The solid was removed by filtration and recrystallized from ca. 35 ml of acetic acid, to give 925 mg of the title compound as yellow crystals, mp 191°-192° C.

Analysis: Calcd. for C₂₀ H₁₂ F₂ N₂ O₄ : C, 62.83; H, 3.16; N, 7.33%. Found: C, 62.70; H, 3.07; N, 7.26%.

EXAMPLE 5

Following substantially the method of Example 1 (Method A), Example 2 or 3 (Method B) or Example 4 (Method C), the following compounds were prepared:

    ______________________________________                                          ##STR9##                                                                                                    Method Melting                                                                 of Prepa-                                                                             Point                                     X       R.sup.1   R.sup.2     ration.sup.1                                                                          (°C.).sup.2                        ______________________________________                                         H       2-furyl   ethyl       B      201-201.5                                 H       2-thienyl ethyl       B      128-129.5                                 H       (2-thienyl)-                                                                             ethyl       B      130-131                                           methyl                                                                 H       methyl    ethyl       B      157-158                                   5-Cl    2-furyl   ethyl       B      134-135                                   5-Cl    2-thienyl ethyl       B      154-155                                   5-Cl    methyl    ethyl       B      173-174                                   5-Cl    (2-thienyl)-                                                                             ethyl       B      154-155                                           methyl                                                                 5-Cl    2-thienyl isopropyl   B      129-130                                   5-Cl    (2-thienyl)-                                                                             isopropyl   B      155-156                                           methyl                                                                 5-Cl    methyl    isopropyl   B      186-187                                   5-Cl    2-furyl   n-butyl     B      100-101                                   5-Cl    2-thienyl n-butyl     B      152-153                                   5-Cl    2-furyl   t-butyl     B      171-171.5                                 H       2-furyl   isopropyl   B      114-115                                   H       2-thienyl isopropyl   B      177-178.5                                 5-Cl    methyl    t-butyl     B      219-220                                   H       2-furyl   t-butyl     B      160-161                                   5-Cl    2-thienyl t-butyl     B      178-179.5                                 H       (2-thienyl)-                                                                             t-butyl     B      141-142d                                          methyl                                                                 H       2-thienyl t-butyl     B      163-164                                   H       methyl    t-butyl     B      163-164                                   5-Cl    (2-thienyl)-                                                                             t-butyl     B      218-219d                                          methyl                                                                 H       methyl    isopropyl   B      162.5-163.5                               H       2-furyl   n-butyl     B      87-88                                     5-Cl    2-thienyl n-butyl     B      123-124                                   5-Cl    methyl    n-butyl     B      167-169                                   H       2-thienyl n-butyl     B      137-138                                   5-Cl    cyclohexyl                                                                               t-butyl     B      239-240d                                  5-Cl    cyclopentyl                                                                              t-butyl     B      229-230d                                  5-Cl    cyclobutyl                                                                               t-butyl     B      226-227d                                  5-CF.sub.3                                                                             2-thienyl t-butyl     B      162-163                                   5-CF.sub.3                                                                             2-furyl   t-butyl     B      171.5-172.5                               5-CF.sub.3                                                                             (2-thienyl)-                                                                             t-butyl     B      133-134                                           methyl                                                                 6-Cl    2-furyl   t-butyl     B      168.5-169.5                               6-Cl    (2-thienyl)-                                                                             t-butyl     B      151-152                                           methyl                                                                 5-Cl    2-furyl   cyclohexyl  B      138-139                                   5-Cl    methyl    cyclohexyl  B      226-227                                   5-Cl    (2-thienyl)-                                                                             cyclohexyl  B      153-154                                           thienyl                                                                5-Cl    2-thienyl cyclohexyl  B      158-159                                   H       methyl    3-(trifluoro-                                                                              A      186-188                                                     methyl)-                                                                       phenyl                                                       H       methyl    2,4-difluoro-                                                                              A      161-162                                                     phenyl                                                       H       methyl    4-fluorophenyl                                                                             A      181-183                                   H       benzyl    phenyl      A      145-147                                   H       (2-thienyl)-                                                                             2,4-difluoro-                                                                              A      165-167                                           methyl    phenyl                                                       H       (2-thienyl)-                                                                             phenyl      A      165-167                                           methyl                                                                 H       isopropyl 4-fluoro-   B      176-177                                                     phenyl                                                       H       cyclopropyl                                                                              4-fluoro-   B      202-203                                                     phenyl                                                       H       2-thienyl phenyl      C      152-153                                   H       2-thienyl 2,4-difluoro-                                                                              C      164-165                                                     phenyl                                                       H       2-furyl   4-chlorophenyl                                                                             C      200.5-                                                                         201.5d                                    H       2-furyl   2-(trifluoro-                                                                              C      202-203d                                                    methyl)phenyl                                                H       trifluoro-                                                                               4-chlorophenyl                                                                             A      202-230                                           methyl                                                                 H       trifluoro-                                                                               2,4-difluoro-                                                                              A      133.5-134.5                                       methyl    phenyl                                                       H       2-thienyl 2-(trifluoro-                                                                              C      166.5-                                                      methyl)phenyl      167.5d                                    H       2-furyl   2,4-dichloro-                                                                              C      235.5d                                                      phenyl                                                       H       2-furyl   3-methoxy-  C      137-138                                                     phenyl                                                       H       2-thienyl 2,4-dichloro-                                                                              C      221.5-                                                      phenyl             222.5d                                    H       2-furyl   4-methoxy-  C      168-169.5                                                   phenyl                                                       H       2-thienyl 4-methoxy-  C      178.5-179.5                                                 phenyl                                                       H       2-furyl   2,4-dimethyl-                                                                              C      176-177                                                     phenyl                                                       H       2-thienyl 2,4-dimethyl-                                                                              C      171-172                                                     phenyl                                                       H       2-furyl   4-ethylphenyl                                                                              C      154.5-155.5                               H       2-thienyl 4-ethylphenyl                                                                              C      131-132                                   H       methyl    4-chlorophenyl                                                                             A      225-227                                   H       phenyl    phenyl      B      176-177                                   H       phenyl    4-chlorophenyl                                                                             B      215-217                                   H       3-pyridyl phenyl      B      193-195                                   H       4-fluoro- 4-chlorophenyl                                                                             B      212-213                                           phenyl                                                                 H       3-pyridyl 4-chlorophenyl                                                                             B      220-221                                   H       4-fluoro- phenyl      B      189-191                                           phenyl                                                                 H       phenyl    2,4-difluoro-                                                                              B      204-206                                                     phenyl                                                       H       benzyl    2,4-difluoro-                                                                              A      151-152                                                     phenyl                                                       H       benzyl    4-chlorophenyl                                                                             A      178-179                                   H       2-thienyl 4-fluorophenyl                                                                             B      175-176.5                                 H       2-furyl   4-fluorophenyl                                                                             B      166.5-                                                                         167.5d                                    H       cyclohexyl                                                                               4-fluorophenyl                                                                             B      180-181                                   H       2-furyl   phenyl      C      162-163                                   H       3-pyridyl 2,4-difluoro-                                                                              C      254d                                                        phenyl                                                       H       trifluoro-                                                                               4-fluorophenyl                                                                             B      203-204                                           methyl                                                                 H       trifluoro-                                                                               phenyl      A      139.5-140.5                                       methyl                                                                 H       phenoxy-  phenyl      A      158-159                                           methyl                                                                 H       phenoxy-  4-chlorophenyl     137.5-138.5                                       methyl                                                                 H       phenoxy-  2,4-difluoro-                                                                              A      137.5-138.5                                       methyl    phenyl                                                       H       (2-thienyl)-                                                                             4-chlorophenyl                                                                             A      165-166                                           methyl                                                                 H       (2-thienyl)-                                                                             4-fluorophenyl                                                                             A      161-163                                           methyl                                                                 H       (2-thienyl)-                                                                             3-tolyl     A      147-149                                           methyl                                                                 H       (2-thienyl)-                                                                             3-fluorophenyl                                                                             A      152-154                                           methyl                                                                 H       (2-thienyl)-                                                                             3-trifluoro-                                                                               A      139-140                                           methyl    methylphenyl                                                 H       1-phenyl- 2,4-difluoro-                                                                              C      152.5-154                                         ethyl     phenyl                                                       H       2-thienyl 4-chlorophenyl                                                                             C      196.5-197.5                               H       1-phenyl- 4-fluorophenyl                                                                             B      166-167                                           ethyl                                                                  H       2-thienyl 3-methoxy-  C      148.5-149.5                                                 phenyl                                                       H       2-furyl   cyclohexyl  B      104-105                                   H       2-thienyl cyclohexyl  B      116-117                                   H       phenoxy-  cyclohexyl  B      159-160                                           methyl                                                                 H       benzyl    cyclohexyl  B      122-123                                   H       4-chloro- phenyl      B      180-181                                           benzyl                                                                 H       4-chloro- 2,4-difluoro-                                                                              B      182-183                                           benzyl    phenyl                                                       H       4-chloro- 4-chlorophenyl                                                                             B      184-186                                           benzyl                                                                 H       4-chloro- 4-fluorophenyl                                                                             B      165-166                                           benzyl                                                                 H       4-fluoro- phenyl      B      179-181                                           benzyl                                                                 H       4-fluoro- 2,4-difluoro-                                                                              B      189-191                                           benzyl    phenyl                                                       H       4-fluoro- 4-chlorophenyl                                                                             B      205-207                                           benzyl                                                                 H       4-fluoro- 4-fluorophenyl                                                                             B      198-199                                           benzyl                                                                 H       (3-thienyl)-                                                                             phenyl      B      133-134                                           methyl                                                                 H       (3-thienyl)-                                                                             2,4-difluoro-                                                                              B      162-163                                           methyl    phenyl                                                       H       (3-thienyl)-                                                                             4-chlorophenyl                                                                             B      182-184                                           methyl                                                                 H       (3-thienyl)-                                                                             4-fluorophenyl                                                                             B      145-147                                           methyl                                                                 H       3-furyl   phenyl      B      145-146                                   H       3-furyl   2,4-difluoro-                                                                              B      178-179                                                     phenyl                                                       H       3-furyl   4-chlorophenyl                                                                             B      190-191                                   H       3-furyl   4-fluorophenyl                                                                             B      189-190                                   H       3-thienyl phenyl      B      166-168                                   H       3-thienyl 2,4-difluoro-                                                                              B      188-190                                                     phenyl                                                       H       3-thienyl 4-chlorophenyl                                                                             B      216-218                                   H       3-thienyl 4-fluorophenyl                                                                             B      209.5-210.5                               H       4-chloro- 4-fluorophenyl                                                                             B      219-220                                           phenyl                                                                 H       methyl    benzyl      B      162-164                                   H       2-thienyl benzyl      B      117-118                                   H       2-furyl   benzyl      B      124-126                                   H       4-pyridyl phenyl      C      212.5-                                                                         213.5d                                    H       4-pyridyl 2,4-difluoro-                                                                              C      229-230                                                     phenyl                                                       H       4-pyridyl 4-chlorophenyl                                                                             C      211-213d                                  H       2-pyridyl phenyl      C      208-209                                   H       2-methyl- phenyl      B      156-157                                           2-furyl                                                                H       2-methyl- 2,4-difluoro-                                                                              B      189-191                                           2-furyl   phenyl                                                       H       2-pyridyl 2,4-difluoro-                                                                              C      230-232d                                                    phenyl                                                       H       2-pyridyl 4-chlorophenyl                                                                             C      207-208d                                  5-CF.sub.3                                                                             bicyclo-  t-butyl     B      212.5d                                            [2.2.1]-                                                                       heptan-2-yl                                                            5-Cl    bicyclo   t-butyl     B      235-236d                                          [2.2.1]-                                                                       heptan-2-yl                                                            6-Cl    bicyclo-  t-butyl     B      225d                                              [2.2.1]-                                                                       heptan-2-yl                                                            5-F     2-furyl   t-butyl     B      184.5-185.5                               5-F     2-thienyl t-butyl     B      183.5d                                    5-F     (2-thienyl)-                                                                             t-butyl     B      182.5-183.5                                       methyl                                                                 6-Cl    2-furyl   isopropyl   B      165.5-166.5                               6-Cl    2-furyl   cyclohexyl  B      164-165                                   5-Cl    2-furyl   phenyl      B      191.5-192.5                               5-Cl    2-furyl   2,4-difluoro-                                                                              B      214-215                                                     phenyl                                                       5-Cl    2-thienyl phenyl      B      194-195                                   5-Cl    (2-thienyl)-          B      167.5-169                                         methyl                                                                 5-Cl    (2-thienyl)-                                                                             2,4-difluoro-                                                                              B      211.5-212.5                                       methyl    phenyl                                                       6-Cl    2-thienyl isopropyl   B      118-119                                   6-Cl    2-thienyl cyclohexyl  B      145-146                                   5-Cl    (3-thienyl)-                                                                             t-butyl     B      222-224                                           methyl                                                                 5-Cl    3-furyl   t-butyl     B      181-182d                                  5-Cl    3-thienyl t-butyl     B      209-211d                                  6-Cl    2-furyl   ethyl       B      157.5-158.5                               6-Cl    2-thienyl ethyl       B      138-139                                   5-Cl    2-chloro- phenyl      B      218-219d                                          benzyl                                                                 5-Cl    2-chloro- 2,4-difluoro-                                                                              B      216d                                              benzyl    phenyl                                                       5-Cl    2-thienyl 2,4-difluoro-                                                                              B      200.5-201.5                                                 phenyl                                                       5-Cl    4-chloro- t-butyl     B      214-216d                                          benzyl                                                                 5-F     2-furyl   isopropyl   B      141-142                                   5-F     2-thienyl isopropyl   B      185-187                                   5-F     (2-thienyl)-                                                                             isopropyl   B      143-144                                           methyl                                                                 5-F     3-furyl   isopropyl   B      163-164                                   5-F     3-thienyl isopropyl   B      179-180.5                                 5-F     (3-thienyl)-                                                                             isopropyl   B      156-157                                           methyl                                                                 6-CF.sub.3                                                                             2-thienyl phenyl      B      187-189                                   6-CF.sub.3                                                                             benzyl    phenyl      B      169-170                                   6-F     2-thienyl phenyl      B      174-175                                   6-F     2-thienyl 4-methoxy-  B      175-176                                                     phenyl                                                       5-C.sub.6 H.sub.5 CO                                                                   benzyl    phenyl      B      167-170                                   5-CH.sub.3 CO                                                                          (2-thienyl)-                                                                             phenyl      B      194-196                                           methyl                                                                 5-Cl    benzyl    4-methoxy-  B      198-200                                                     phenyl                                                       5-Cl    (2-thienyl)-                                                                             4-methoxy-  B      195-197                                           methyl    phenyl                                                       5-F     2-thienyl phenyl      B      164-166                                   5-F     2-thienyl 4-methoxy-  B      177-179                                                     phenyl                                                       5-NO.sub.2                                                                             phenoxy-  phenyl      B      224-225                                           methyl                                                                 5-C.sub.6 H.sub.5 CO                                                                   2-thienyl phenyl      B      160-163                                   5-C.sub.6 H.sub.5 CO                                                                   (2-thienyl)-                                                                             phenyl      B      171-173                                           methyl                                                                 5-CH.sub.3 CO                                                                          2-thienyl phenyl      B      193-195                                   5-CH.sub.3 CO                                                                          benzyl    phenyl      B      195-198                                   5-Cl    2-thienyl 4-methoxy-  B      185-187                                                     phenyl                                                       5-Cl    benzyl    phenyl      B      156-158                                   5-F     benzyl    phenyl      B      175-177                                   5-Cl    4-chloro- phenyl      B      239-240                                           phenyl                                                                 6-F     2-tetra-  4-methoxy-  B      170-172                                           hydro-    phenyl                                                               furanyl                                                                ______________________________________                                          .sup.1 The letter "A" in this column indicates that the compound was           prepared substantially according to Example 1; the letter "B" indicates        that the compound was prepared substantially according to Example 2 or 3;      and the letter "C" indicates that the compound was prepared substantially      according to Example 4. In Method B triethylamine was used as the acid         scavenger instead of 4(N,Ndimethylamino)pyridine in several cases.             .sup.2 The letter "d" indicates that the compound melted with                  decomposition.                                                           

EXAMPLE 5 (Cont.)

In like manner, following substantially the method of Example 2, the following compounds were prepared:

    ______________________________________                                          ##STR10##                                                                                                          Melting                                   X     Y      R.sup.1      R.sup.2    Point (°C.)                        ______________________________________                                         4-Cl  5-F    (2-thienyl)methyl                                                                           phenyl     154                                       5-F   6-Cl   benzyl       phenyl     203-204                                   5-F   6-Cl   2-thienyl    phenyl     212-214                                   5-F   6-Cl   benzyl       n-butyl    129-130                                   5-F   6-Cl   2-furyl      n-butyl    122-123                                   5-F   6-Cl   benzyl       4-methoxyphenyl                                                                           194-196                                   5-F   6-Cl   2-thienyl    4-methoxyphenyl                                                                           210-212                                   ______________________________________                                    

EXAMPLE 6

By the reaction of the appropriate 3-acyl-2-oxindole with the requisite isocyanate of formula R² --N═C═O, using the procedure of Example 1, the following compounds can be prepared.

    ______________________________________                                          ##STR11##                                                                     X     Y       R.sup.1      R.sup.2                                             ______________________________________                                         H     H       isobutyl     n-propyl                                            H     H       cycloheptyl  2-fluoro-4-chlorophenyl                             H     H       3-phenylpropyl                                                                              n-hexyl                                             5-F   H       2-furyl      cyclopropyl                                         5-F   H       cyclopentyl  n-hexyl                                             5-F   H       3-furyl      3-ethoxyphenyl                                      6-F   H       (3-thienyl)methyl                                                                           4-n-butoxyphenyl                                    6-F   H       (2-furyl)methyl                                                                             phenyl                                              6-Cl  H       2-furyl      3-chloro-4-methoxyphenyl                            5-Br  H       (3-furyl)methyl                                                                             cyclobutyl                                          6-Br  H       n-hexyl      methyl                                              5-CF.sub.3                                                                           H       n-butyl      4-n-butylphenyl                                     6-CF.sub.3                                                                           H       3-thienyl    cycloheptyl                                         6-CF.sub.3                                                                           H       cyclopropyl  isobutyl                                            6-CF.sub.3                                                                           H       ethyl        3-methylphenyl                                      6-CF.sub.3                                                                           H       1-phenylethyl                                                                               phenyl                                              7-F   H       2-thienyl    phenyl                                              4-Cl  H       2-furyl      cyclohexyl                                          5-Cl  6-Cl    benzyl       t-butyl                                             5-CH.sub.3                                                                           6-CH.sub.3                                                                             (2-thienyl)methyl                                                                           isopropyl                                           ______________________________________                                    

EXAMPLE 7

By reaction of the appropriate N-substituted-2-oxindole-1-carboxamide with the requisite acid chloride of formula R¹ --CO--Cl, using the procedure of Example 2, the following compounds can be prepared.

    __________________________________________________________________________      ##STR12##                                                                     X          Y     R.sup.1       R.sup.2                                         __________________________________________________________________________     H          H     cyclohexyl    phenyl                                          H          H     3-furyl       cyclohexyl                                      H          H     3-thienyl     2-fluorophenyl                                  5-F        H     isobutyl      4-methoxyphenyl                                 5-F        H     cyclopentyl   3,4-dichlorophenyl                              5-F        H     3-thienyl     cycloheptyl                                     6-F        H     (3-thienyl)methyl                                                                            4-chlorophenyl                                  6-Cl       H     cyclopropyl   3-methylphenyl                                  5-Br       H     2-furyl       methyl                                          6-Br       H     n-hexyl       cyclopropyl                                     6-Br       H     (3-furyl)methyl                                                                              phenyl                                          5-CF.sub.3 H     cycloheptyl   3-n-butoxyphenyl                                5-CF.sub.3 H     (2-furyl)methyl                                                                              2,4-difluorophenyl                              6-CF.sub.3 H     (2-thienyl)methyl                                                                            n-hexyl                                         6-CF.sub.3 H     2-furyl       4-n-butylphenyl                                 6-CF.sub.3 H     cyclohexyl    3-chloro-4-fluorophenyl                         H          H     n-hexyl       3-butoxyphenyl                                  5-Br       H     cycloheptyl   4-isobutylphenyl                                H          5-Br  cyclobut-1-enyl                                                                              methyl                                          n-C.sub.4 H.sub.9                                                                         H     phenyl        ethyl                                           H          5-C.sub.2 H.sub.5 O                                                                  2-thienyl     n-hexyl                                         6-n-C.sub.4 H.sub.9 O                                                                     H     2-furyl       cyclopropyl                                     H          5-n-C.sub.4 H.sub.9 O                                                                3-thienyl     cyclopentyl                                     5-CH.sub.3 O                                                                              6-CH.sub.3 O                                                                         ethyl         cyclohexyl                                      7-Cl       H     phenyl        propyl                                          4-CH.sub.3 S                                                                              H     5-methylhexyl phenyl                                          H          6-CH.sub.3 S                                                                         ethyl         3-chlorophenyl                                  5-n-C.sub. 4 H.sub.9 S                                                                    H     cyclohexyl    3-fluorophenyl                                  H          H     3-phenylpropyl                                                                               cycloheptyl                                     5-Cl       H     3-phenoxypropyl                                                                              butyl                                           5-F        H     5-propyl-2-furyl                                                                             phenyl                                          5-Cl       6-Cl  thiophenoxy-methyl                                                                           phenyl                                          5-CH.sub.3 H     4-methyl-2-thienyl                                                                           cyclohexyl                                      H          H     3-methyl-2-thienyl                                                                           4-ethylphenyl                                   4-Cl       H     5-propyl-2-thienyl                                                                           phenyl                                          6-Cl       H     (2-furyl)methyl                                                                              cyclobutyl                                      6-Cl       H     3-(2-furyl)propyl                                                                            n-pentyl                                        5-F        H     2-(2-thienyl)ethyl                                                                           4-chlorophenyl                                  6-Cl       H     3-(2-thienyl)propyl                                                                          4-methoxyphenyl                                 H          H     1-naphthyl    phenyl                                          5-Cl       H     2-naphthyl    cyclohexyl                                      5-CH.sub.3 H     2-benzo[b]-furyl                                                                             n-hexyl                                         5-F        H     3-benzo[b]-furyl                                                                             phenyl                                          H          H     2-benzo[b]-thienyl                                                                           cyclohexyl                                      5-CH.sub.3 H     3-benzo[b]-thienyl                                                                           n-hexyl                                         H          H     ethyl         3,4-dichlorophenyl                              4-CH.sub.3 5-CH.sub.3                                                                           phenyl        cyclohexyl                                      5-Cl       H     2-thienyl     3,4-diethoxyphenyl                              5-CH.sub.3 6-CH.sub.3                                                                           cyclohept-1-enyl                                                                             phenyl                                          5-F        H     2-furyl       3-fluoro-4-chlorophenyl                         5-OCH.sub.3                                                                               H     butyl         cyclobutyl                                      5-CF.sub.3 H     (2-thienyl)methyl                                                                            2,4-difluorophenyl                              6-Cl       H     2-naphthyl    3,5-dichlorophenyl                              5-F        6-Cl  3-(thiophenoxy)propyl                                                                        cyclohexyl                                      6-Cl       H     bicyclo[2.2.1]-hept-5-en-2-yl                                                                t-butyl                                         6-Br       H     benzyl        ethyl                                           H          H     2-furyl       3-ethoxy-4-butoxyphenyl                         5-Cl       6-Cl  2-imidazolyl  4-methoxyphenyl                                 6-F        H     n-hexyl       cyclohexyl                                      5-F        6-Cl  2-thienyl     2,4-dimethylphenyl                              6-CF.sub.3 H     3-pyrazolyl   4-chlorophenyl                                  5-CH.sub.3 6-F   cyclohexyl    3,5-dimethylphenyl                              6-OCH.sub.3                                                                               H     2-furyl       cycloheptyl                                     H          H     2-thienyl     4-trifluoromethylphenyl                         5-Cl       H     2-pyrrolyl    phenyl                                          5-CH.sub.3 SO                                                                             H     2-thienyl     phenyl                                          5-n-C.sub.4 H.sub.9 SO                                                                    H     2-furyl       cyclohexyl                                      4-CH.sub.3 SO.sub.2                                                                       H     3-fluorophenyl                                                                               phenoxymethyl                                   5-n-C.sub.4 H.sub.9 SO.sub.2                                                              H     2-thiazolyl   phenyl                                          5-NO.sub.2 H     2-(3-thienyl)ethyl                                                                           cyclohexyl                                      6-C.sub.6 H.sub.5                                                                         H     4-chlorophenyl                                                                               2-furyl                                         H          5-Br  2-(2-tolyl)ethyl                                                                             cyclohexyl                                      5-CH.sub.3 CO                                                                             H     4-trifluoromethylphenyl                                                                      phenyl                                          6-n-C.sub.3 H.sub.7 CO                                                                    H     4-isothiazolyl                                                                               n-hexyl                                         5-Cl       H     1-naphthyl    3-thienyl                                       5-C.sub.6 H.sub.5 CO                                                                      H     1,2,3-thiadiazol-4-yl                                                                        cyclohexyl                                      5-C.sub.4 H.sub.3 SCO.sup.1                                                               H     3-(3-chlorophenyl)propyl                                                                     3-methylphenyl                                  6-CF.sub.3 H     (4-thiazolyl)methyl                                                                          4-chlorophenyl                                  6-F        H     1,2,5-thiadiazol-3-yl                                                                        cyclohexyl                                      5-Cl       H     1,3,4-thiadiazol-2-yl                                                                        phenyl                                          5-CH.sub.3 CONH                                                                           H     1-methyl-1-phenylethyl                                                                       ethyl                                           5-Cl       6-Cl  5-methyl-4-isoxazolyl                                                                        4-methoxyphenyl                                 5-(CH.sub.3).sub.2 CHCONH                                                                 H     2-(4-isobutylphenyl)ethyl                                                                    phenyl                                          5-C.sub.6 H.sub.5 CONH                                                                    H     2-thienyl     phenyl                                          5-CH.sub.3 6-CH.sub.3                                                                           4-isobutoxyphenyl                                                                            3-pyridyl                                       5-SO.sub.2 N(CH.sub.3).sub.2                                                              H     benzyl        phenyl                                          5-F        6-F   4-chlorophenoxy                                                                              2-methylphenyl                                  5-SO.sub.2 N(n-C.sub.3 H.sub.7).sub.2                                                     H     2-tetrahydrofuryl                                                                            n-hexyl                                         H          4-Cl  4-pyridyl     phenyl                                          6-Cl       H     3-tetrahydrothienyl                                                                          3,5-dichlorophenyl                              H          H     5-pyrimidyl   cyclohexyl                                      5-CH.sub.3 6-F   2-pyrazinyl   3,5-dimethylphenyl                              H          H     2-n-propyl-4-thiazolyl                                                                       phenyl                                          5-Br       H     2-oxazolyl    4-isobutylphenyl                                H          H     3-isoxazolyl  phenyl                                          5-F        6-Cl  2-tetrahydropyranyl                                                                          cyclopentyl                                     5-CH.sub.3 6-CH.sub.3                                                                           2-tetrahydrothiopyranyl                                                                      t-butyl                                         __________________________________________________________________________      .sup.1 5-(2-thenoyl)                                                     

EXAMPLE 8

By reaction of 2-furoyl chloride with N-phenyl 5,6-methylenedioxy-2-oxindole-1-carboxamide, N-cyclo-hexyl-5,6-ethylenedioxy-2-oxindole-1-carboxamide, N-t-butyl-5-cyclopropyl-2-oxindole-1-carboxamide and N-isobutyl-5-cycloheptyl-2-oxindole-1-carboxamide, respectively, using the method of Example 2, the following compounds can be prepared:

N-phenyl-3-(2-furoyl)-5,6-methylenedioxy-2-oxindole-1-carboxamide,

N-cyclohexyl-3-(2-furoyl)-5,6-ethylenedioxy-2-oxindole-1-carboxamide,

N-t-butyl-3-(2-furoyl)-5-cyclopropyl-2-oxindole-1-carboxamide and

N-isobutyl-3-(2-furoyl)-5-cycloheptyl-2-oxindole-1-carboxamide, respectively.

EXAMPLE 9

The compounds in the Table below can be prepared by reaction of the appropriate acid chloride with the requisite N-substituted-2-oxindole-1-carboxamide, using the procedure of Example 2.

    ______________________________________                                          ##STR13##                                                                     X and Y*          R.sup.1    R.sup.2                                           ______________________________________                                         4-CH.sub.2CH.sub.2CH.sub.25                                                                      2-furyl    phenyl                                            5-CH.sub.2CH.sub.2CH.sub.26                                                                      2-thienyl  cyclohexyl                                        6-CH.sub.2CH.sub.2CH.sub.2CH.sub.27                                                              2-furyl    4-fluorophenyl                                    5-CHCHCHCH6       (2-thienyl)-                                                                              t-butyl                                                             methyl                                                       5-OCH.sub.2CH.sub.26                                                                             2-thienyl  isopropyl                                         5-CH.sub.2CH.sub.2O6                                                                             2-furyl    phenyl                                            5-SCH.sub.2CH.sub.26                                                                             2-thienyl  cyclohexyl                                        5-OCHCH6          2-furyl    t-butyl                                           5-SCHCH6          (2-thienyl)-                                                                              cyclohexyl                                                          methyl                                                       5-CHCHS6          2-furyl    phenyl                                            ______________________________________                                          *In this column, the numeral to the left of the formula indicates the          point of attachment of that end of the formula to the 2oxindole nucleus        and the numeral to the right indicates the point of attachment of that en      of the formula to the 2oxindole nucleus.                                 

EXAMPLE 10 Ethanolamine Salt of N-t-Butyl-6-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide

To a slurry of 3.77 g of N-t-butyl-6-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide in 60 ml of methanol is added 610 mg of ethanolamine. The resulting mixture is heated to boiling for 5 minutes, and then it is allowed to cool. The solid is collected by filtration to give the title salt.

EXAMPLE 11 N-Isopropyl-2-oxindole-1-carboxamide

To a stirred suspension of 5.0 g (37.6 mmole) of 2-oxindole in 50 ml of toluene was added 8.0 g (94.0 mmole) of isopropyl isocyanate, and the mixture was heated under reflux for 6 hours. The reaction mixture was allowed to cool and then it was stirred at room temperature overnight. The solvent was removed by evaporation in vacuo, and the residue was dissolved in hot cyclohexane. The solution was allowed to cool and the solid was collected by filtration, giving 7.0 g of the title compound, mp 84°-85.5° C., as pink crystals.

EXAMPLE 12

By reaction of the appropriate 2-oxindole with the requisite isocyanate of the formula R² -N═C═O, substantially according to the procedure of Example 11, the following compounds were prepared:

    ______________________________________                                          ##STR14##                                                                                                 Reaction                                                                               Melting                                    X      Y       R.sup.2      solvent point (°C.)                         ______________________________________                                         6-Cl   H       t-butyl      xylene  124-125.sup.1                              H      H       4-fluorophenyl                                                                              toluene 145-146.sup.2                              H      H       ethyl        benzene 98-99                                      5-Cl   H       ethyl        xylene  121-122                                    5-Cl   H       isopropyl    xylene  164-165                                    5-Cl   H       n-butyl      xylene  67-68                                      5-Cl   H       t-butyl      xylene  153-154                                    H      H       t-butyl      toluene 60-62                                      H      H       n-butyl      toluene 49-51                                      5-CF.sub.3                                                                            H       t-butyl      xylene  116-117                                    5-Cl   H       cyclohexyl   xylene  139-140                                    ______________________________________                                          .sup.1 product was purified by column chromatography.                          .sup.2 product precipitated at end of reaction and was recovered by            filtration.                                                              

EXAMPLE 13

By the reaction of the appropriate 2-oxindole with the requisite isocyanate of the formula R² -N═C═O, using the procedure of Example 11, the following compounds can be prepared:

    ______________________________________                                          ##STR15##                                                                     X            Y          R.sup.2                                                ______________________________________                                         H            H          phenyl                                                 H            H          cyclohexyl                                             H            H          2-fluorophenyl                                         5-F          H          4-methoxyphenyl                                        5-F          H          3,4-dichlorophenyl                                     5-F          H          cycloheptyl                                            6-F          H          4-chlorophenyl                                         6-Cl         H          3-methylphenyl                                         5-Br         H          methyl                                                 6-Br         H          cyclopropyl                                            6-Br         H          phenyl                                                 5-CF.sub.3   H          3-n-butoxyphenyl                                       5-CF.sub.3   H          2,4-difluorophenyl                                     6-CF.sub.3   H          n-hexyl                                                6-CF.sub.3   H          4-n-butylphenyl                                        6-CF.sub.3   H          3-chloro-4-fluorophenyl                                H            H          3-butoxyphenyl                                         5-Br         H          4-isobutylphenyl                                       H            5-Br       methyl                                                 n-C.sub.4 H.sub.9                                                                           H          ethyl                                                  H            5-C.sub.2 H.sub.5 O                                                                       n-hexyl                                                6-n-C.sub.4 H.sub.9 O                                                                       H          cyclopropyl                                            H            5-n-C.sub.4 H.sub.9 O                                                                     cyclopentyl                                            5-CH.sub.3 O 6-CH.sub.3 O                                                                              cyclohexyl                                             7-Cl         H          propyl                                                 4-CH.sub.3 S H          phenyl                                                 5-n-C.sub.4 H.sub.9 S                                                                       H          3-fluorophenyl                                         H            H          cycloheptyl                                            5-Cl         H          butyl                                                  H            H          4-ethylphenyl                                          4-Cl         H          phenyl                                                 6-Cl         H          cyclobutyl                                             6-Cl         H          n-pentyl                                               5-F          H          4-chlorophenyl                                         6-Cl         H          4-methoxyphenyl                                        5-CH.sub.3   H          n-hexyl                                                5-Cl         6-Cl       phenyl                                                 5-Cl         6-Cl       cyclohexyl                                             5-Cl         H          phenyl                                                 5-F          6-Cl       cyclopentyl                                            5-CH.sub.3   6-CH.sub.3 t-butyl                                                H            H          3,4-dichlorophenyl                                     4-CH.sub.3   5-CH.sub.3 cyclohexyl                                             5-Cl         H          3,4-diethoxyphenyl                                     5-CH.sub.3   6-CH.sub.3 phenyl                                                 5-F          H          3-fluoro-4-chlorophenyl                                5-OCH.sub.3  H          cyclobutyl                                             5-CF.sub.3   H          2,4-difluorophenyl                                     6-Cl         H          3,5-dichlorophenyl                                     6-Br         H          ethyl                                                  H            H          3-ethoxy-4-butoxyphenyl                                5-Cl         6-Cl       4-methoxyphenyl                                        6-F          H          cyclohexyl                                             5-F          6-Cl       2,4-dimethylphenyl                                     6-CF.sub.3   H          4-chlorophenyl                                         5-CH.sub.3   6-F        3,5-dimethylphenyl                                     6-OCH.sub.3  H          cycloheptyl                                            H            H          4-trifluoromethylphenyl                                5-CH.sub.3 SO                                                                               H          phenyl                                                 5-n-C.sub.4 H.sub.9 SO                                                                      H          cyclohexyl                                             4-CH.sub.3 SO.sub.2                                                                         H          phenoxymethyl                                          5-n-C.sub.4 H.sub.9 SO.sub.2                                                                H          phenyl                                                 5-NO.sub.2   H          cyclohexyl                                             6-C.sub.6 H.sub.5                                                                           H          2-furyl                                                H            5-Br       cyclohexyl                                             5-CH.sub.3 CO                                                                               H          phenyl                                                 6-n-C.sub.3 H.sub.7 CO                                                                      H          n-hexyl                                                5-Cl         H          3-thienyl                                              5-C.sub.6 H.sub.5 CO                                                                        H          cyclohexyl                                             5-C.sub.4 H.sub.3 SCO.sup.1                                                                 H          3-methylphenyl                                         5-CH.sub.3 CONH                                                                             H          ethyl                                                  5-(CH.sub.3).sub.2 CHCONH                                                                   H          phenyl                                                 5-C.sub.6 H.sub.5 CONH                                                                      H          phenyl                                                 5-CH.sub.3   6-CH.sub.3 3-pyridyl                                              5-SO.sub.2 N(CH.sub.3).sub.2                                                                H          phenyl                                                 5-F          6-F        2-methylphenyl                                         5-SO.sub.2 N(n-C.sub.3 H.sub.7).sub.2                                                       H          n-hexyl                                                ______________________________________                                          .sup.1 5-(2-thenoyl)                                                     

EXAMPLE 14

By reaction of 5,6-methylenedioxy-2-oxindole with phenyl isocyanate, 5,6-ethylenedioxy-2-oxindole with cyclohexyl isocyanate, 5-cyclopropyl-2-oxindole with phenyl isocyanate and 5-cycloheptyl-2-oxindole with isobutyl isocyanate, using the procedure of Example 11, the following compounds can be prepared:

N-phenyl-5,6-methylenedioxy-2-oxindole-1-carboxamide,

N-cyclohexyl-5,6-ethylenedioxy-2-oxindole-1-carboxamide,

N-phenyl-5-cyclopropyl-2-oxindole-1-carboxamide and

N-isobutyl-5-cycloheptyl-2-oxindole-1-carboxamide, respectively.

EXAMPLE 15

The N-substituted-2-oxindole-1-carboxamides in the table below can be prepared by reaction of the corresponding 2-oxindole compound with the requisite isocyanate, using the procedure of Example 11.

    ______________________________________                                          ##STR16##                                                                     X and Y*              R.sup.2                                                  ______________________________________                                         4-CH.sub.2CH.sub.2CH.sub.25                                                                          phenyl                                                   5-CH.sub.2CH.sub.2CH.sub.26                                                                          cyclohexyl                                               6-CH.sub.2CH.sub.2CH.sub.2CH.sub.27                                                                  4-fluorophenyl                                           5-CHCHCHCH6           t-butyl                                                  5-OCH.sub.2CH.sub.26  isopropyl                                                5-CH.sub.2CH.sub.2O6  phenyl                                                   5-SCH.sub.2CH.sub.26  cyclohexyl                                               5-OCHCH6              t-butyl                                                  5-SCHCH6              cyclohexyl                                               5-CHCHS6              phenyl                                                   ______________________________________                                          *In this column, the numeral to the left of the formula indicates the          point of attachment of that end of the formula to the 2oxindole nucleus        and the numeral to the right indicates the point of attachment of that en      of the formula to the 2oxindole nucleaus.                                

PREPARATION 1 3-(2-Furoyl)-2-oxindole

To a stirred solution of 5.5 g (0.24 mole) of sodium in 150 ml of ethanol was added 13.3 g (0.10 mole) of 2-oxindole at room temperature. The resulting slurry was cooled to ice-bath temperature, and then 15.7 g (0.12 mole) of 2-furoyl chloride was added, dropwise, during 10-15 minutes. The ice-bath was removed, and an additional 100 ml of ethanol was added and then the reaction mixture was heated under reflux for 7 hours. The reaction mixture was allowed to stand overnight and then the solid was filtered off. The solid was added to 400 ml of water and the resulting mixture was acidified using concentrated hydrochloric acid. The mixture was cooled with ice and the solid was collected by filtration. The solid residue was recrystallized from 150 ml of acetic acid, affording 8.3 g of yellow crystals, m.p. 209°-210° C. (dec.).

Analysis: Calcd. for C₁₃ H₉ O₃ N: C, 68.72; H, 3.99; N, 6.17%. Found: C, 68.25; H, 4.05; N, 6.20%.

PREPARATION 2

Reaction of 2-oxindole with the appropriate acid chloride using the method of Preparation 1, gave the following additional products:

3-(2-thenoyl)-2-oxindole, m.p. 189°-190° C., 17% yield;

3-(2-[2-thienyl]acetyl)-2-oxindole, m.p. 191°-192.5° C., 38% yield;

3-(2-phenoxyacetyl)-2-oxindole, m.p. 135°-136° C., 42% yield; and

5-chloro-3-(2-[2-thienyl]acetyl)-2-oxindole, m.p. 228°-230° C., 22% yield.

PREPARATION 3 3-(3-Furoyl)-2-oxindole

To a stirred solution of 2.8 g (0.12 mole) of sodium in 200 ml of ethanol was added 13.3 g (0.10 mole) of 2-oxindole, followed by 16.8 g of ethyl 3-furoate. The mixture was heated under reflux for 47 hours, cooled and then the solvent was removed by evaporation in vacuo. The residue was triturated under 200 ml of ether, and the solid was collected by filtration and discarded. The filtrate was evaporated in vacuo, and the residue triturated under isopropyl alcohol and recovered by filtration. The solid was suspended in 250 ml of water, which was then acidified with concentrated hydrochloric acid. This mixture was stirred to give a solid, which was recovered by filtration. This latter solid was recrystallized from acetic acid followed by acetonitrile to give 705 mg of the title compound, m.p. 185°-186° C.

Analysis: Calcd. for C₁₃ H₉ O₃ N: C, 68.72; H, 3.99; N, 6.17%. Found: C, 68.72; H, 4.14; N, 6.14%.

PREPARATION 4

Reaction of the appropriate 2-oxindole with the ethyl ester of the requisite carboxylic acid, substantially according to the procedure of Preparation 3 gave the following compounds:

5-chloro-3-(2-thenoyl)-2-oxindole, m.p. 190.5°-192° C., 36% yield;

5-chloro-3-(2-furoyl)-2-oxindole, m.p. 234°-235° C., 54% yield;

5-chloro-3-(2-phenylacetyl)-2-oxindole, m.p. 241°-243° C., 61% yield;

5-fluoro-3-(2-furoyl)-2-oxindole, m.p. 222°-224° C., 51% yield;

5-fluoro-3-(2-thenoyl)-2-oxindole, m.p. 200°-203° C., 26% yield;

6-fluoro-3-(2-furoyl)-2-oxindole, m.p. 239°-242° C., 26% yield; and

6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole, m.p. 212°-215° C., 20% yield.

In like manner, using the requisite 2-oxindole and ethyl ester, and following substantially the method of Preparation 3, the following compounds can be prepared:

5-trifluoromethyl-3-(2-furoyl)-2-oxindole; and

6-trifluoromethyl-3-(3-thenoyl)-2-oxindole.

PREPARATION 5 3-Trifluoroacetyl-2-oxindole

Sodium (3.0 g, 0.13 mole) was dissolved in 150 ml of ethanol, and then 13.3 g (0.10 mole) of 2-oxindole was added at room temperature, with stirring. The resulting mixture was cooled in an ice-bath and 18.5 g (0.13 mole) of ethyl 2,2,2-trifluoroacetate was added rapidly with stirring. The cooling bath was removed, and the reaction mixture was heated to the reflux temperature of the solvent and held there for 1 hour. At this point, the reaction mixture was cooled and the bulk of the solvent was removed by evaporation in vacuo. The residue was added to 300 ml of water, to which was then added 100 ml of concentrated hydrochloric acid. The resulting mixture was cooled in an ice-bath and then the solid was collected by filtration. The latter solid was dissolved in ethyl acetate, and the ethyl acetate solution was washed with saturated sodium chloride and then dried using magnesium sulfate. The dried solution was evaporated in vacuo, and the residue was recrystallized from toluene, to give 13.2 g of the title compound as yellow crystals, m.p. 183.5°-184.5° C.

Analysis: Calcd. for C₁₀ H₆ F₃ NO₂ : C, 52.41; H, 2.64; N, 6.11%. Found: C, 52.52; H, 2.75; N, 6.04%.

PREPARATION 6

By reacting the appropriate 2-oxindole with the requisite acid chloride of the formula R¹ --CO--Cl, using the procedure of Preparation 1, the following compounds can be prepared.

    ______________________________________                                          ##STR17##                                                                     X                 R.sup.1                                                      ______________________________________                                         H                 isobutyl                                                     H                 cycloheptyl                                                  H                 3-phenylpropyl                                               5-F               2-furyl                                                      5-F               cyclopentyl                                                  5-F               3-furyl                                                      6-F               (3-thienyl)methyl                                            6-F               (2-furyl)methyl                                              6-Cl              2-furyl                                                      5-Br              (3-furyl)methyl                                              6-Br              n-hexyl                                                      5-CF.sub.3        n-butyl                                                      6-CF.sub.3        3-thienyl                                                    6-CF.sub.3        cyclopropyl                                                  6-CF.sub.3        ethyl                                                        6-CF.sub.3        1-phenylethyl                                                ______________________________________                                    

PREPARATION 7 5-Chloro-2-oxindole

To a stirred slurry of 100 g (0.55 mol) of 5-chloroisatin in 930 ml of ethanol was added 40 ml (0.826 mol) of hydrazine hydrate, resulting in a red solution. The solution was heated under reflux for 3.5 hours, during which time a precipitate appeared. The reaction mixture was stirred overnight, and then the precipitate was recovered by filtration to give 5-chloro-3-hydrazono-2-oxindole as a yellow solid, which was dried in a vacuum oven. The dried solid weighed 105.4 g.

The dried solid was then added portionwise, during 10 minutes, to a solution of 125.1 g of sodium methoxide in 900 ml of absolute ethanol. The resultant solution was heated under reflux for 10 minutes and then it was concentrated in vacuo to a gummy solid. The gummy solid was dissolved in 400 ml of water and the aqueous solution thus obtained was decolorized with activated carbon and then poured into a mixture of 1 liter of water and 180 ml of concentrated hydrochloric acid containing ice chips. A tan solid precipitated and it was collected by filtration and washed thoroughly with water. The solid was dried and then it was washed with diethyl ether. Finally it was recrystallized from ethanol to give 48.9 g of the title compound, m.p. 193°-195° C. (dec).

In an analogous fashion, 5-methylisatin was converted into 5-methyl-2-oxindole by treatment with hydrazine hydrate followed sodium ethoxide in ethanol. The product melted at 173°-174° C.

PREPARATION 8 4,5-Dimethyl-2-oxindole and 5,6-Dimethyl-2-oxindole

3,4-Dimethylaniline was converted into 3,4-dimethyl-isonitrosoacetanilide by reaction with chloral hydrate and hydroxylamine, using the method described in "Organic Syntheses," Collective Volume I, page 327. The 3,4-dimethyl-isonitrosoacetanilide was cyclized with sulfuric acid, according to the method of Baker et al., Journal of Organic Chemistry, 17, 149 (1952), to give 4,5-dimethylisatin (m.p. 225°-226° C.) and 5,6-dimethylisatin (m.p. 217°-218° C.).

4,5-Dimethylisatin was converted into 4,5-dimethyl-2-oxindole, m.p. 245.5-247.5° C., by treatment with hydrazine hydrate, followed by sodium ethoxide in ethanol, substantially according to the procedure of Preparation 7.

In like manner, 5,6-dimethylisatin was converted into 5,6-dimethyl-2-oxindole, m.p. 196.5°-198° C., by treatment with hydrazine hydrate, followed by sodium ethoxide in ethanol, substantially according to the procedure of Preparation 7.

PREPARATION 9 4-Chloro-2-oxindole and 6-Chloro-2-oxindole A. 3-Chloro-isonitrosoacetanilide

To a stirred solution of 113.23 g (0.686 mol) of chloral hydrate in 2 liters of water was added 419 g (2.95 mol) of sodium sulfate, followed by a solution prepared from 89.25 g (0.70 mol) of 3-chloroaniline, 62 ml of concentrated hydrochloric acid and 500 ml of water. A thick precipitate formed. To the reaction mixture was then added, with stirring, a solution of 155 g (2.23 mol) of hydroxylamine in 500 ml of water. Stirring was continued and the reaction mixture was warmed slowly and it was maintained between 60 and 75° C. for approximately 6 hours, during which time an additional 1 liter of water had been added to facilitate stirring. The reaction mixture was then cooled and the precipitate was recovered by filtration. The wet solid was dried to give 136.1 g of 3-chloro-isonitrosoacetanilide.

B. 4-Chloroisatin and 6-chloroisatin

To 775 ml of concentrated sulfuric acid, preheated to 70° C., was added, with stirring, 136 g of 3-chloro-isonitrosoacetanilide at such a rate as to maintain the reaction medium at a temperature between 75 and 85° C. When all the solid had been added, the reaction mixture was heated at 90° C. for an additional 30 minutes. The reaction mixture was then cooled, and poured slowly onto ca. 2 liters of ice, with stirring. Additional ice was added as necessary to maintain the temperature below room temperature. A red-orange precipitate formed which was recovered by filtration, washed with water and dried. The resultant solid was slurried in 2 liters of water, and then it was brought into solution by the addition of ca. 700 ml of 3N sodium hydroxide. The solution was filtered, and then pH was adjusted to 8 with concentrated hydrochloric acid. At this point, 120 ml of a mixture of 80 parts water and 20 parts concentrated hydrochloric acid was added. The solid which precipitated was recovered by filtration, washed with water and dried to give 50 g of crude 4-chloroisatin. The filtrate from which the 4-chloroisatin had been recovered was further acidified to pH 0 using concentrated hydrochloric acid, whereupon a further precipitate formed. It was recovered by filtration, washed with water and dried, to give 43 g of crude 6-chloroisatin.

The crude 4-chloroisatin was recrystallized from acetic acid to give 43.3 g of material melting at 258°-259° C.

The crude 6-chloroisatin was recrystallized from acetic acid to give 36.2 g of material melting at 261°-262° C.

C. 4-Chloro-2-oxindole

To a stirred slurry of 43.3 g of 4-chloroisatin in 350 ml of ethanol was added 17.3 ml of hydrazine hydrate, and then the reaction mixture was heated under reflux for 2 hours. The reaction mixture was cooled, and the precipitate was recovered by filtration to give 43.5 g of 4-chloro-3-hydrazono-2-oxindole, m.p. 235°-236° C.

To a stirred solution of 22 g of sodium in 450 ml of anhydrous ethanol was added, portionwise, 43.5 g of 4-chloro-3-hydrazono-2-oxindole, and the resulting solution was heated under reflux for 30 minutes. The cooled solution was then concentrated to a gum, which was dissolved in 400 ml of water and decolorized using activated carbon. The resulting solution was poured onto a mixture of 1 liter of water and 45 ml of concentrated hydrochloric acid. The precipitate which formed was recovered by filtration, dried and recrystallized from ethanol, giving 22.4 g of 4-chloro-2-oxindole, m.p. 216°-218° C. (dec).

D. 6-Chloro-2-oxindole

Reaction of 36.2 g of 6-chloroisatin with hydrazine hydrate followed by sodium ethoxide in ethanol, substantially according to C above, afforded 14.2 g of 6-chloro-2-oxindole, m.p. 196°-198° C.

PREPARATION 10 5,6-Difluoro-2-oxindole

Reaction of 3,4-difluoroaniline with chloral hydrate and hydroxylamine followed cyclization with sulfuric acid, in a manner analogous to Parts A and B of Preparation 9, gave 5,6-difluoroisatin, which was reacted with hydrazine hydrate followed by sodium methoxide in ethanol, in a manner analogous to Preparation 7, to give the title compound, m.p. 187°-190° C.

PREPARATION 11 5-Fluoro-2-oxindole

To a stirred solution of 11.1 g (0.1 mol) of 4-fluoroaniline in 200 ml of dichloromethane, at -60° to -65° C., was added, dropwise, a solution of 10.8 g (0.1 mol) of t-butyl hypochlorite in 25 ml of dichloromethane. Stirring was continued for 10 minutes at -60° to -65° C., and then was added, dropwise, a solution of 13.4 g (0.1 mol) of ethyl 2-(methylthio)acetate in 25 ml of dichloromethane. Stirring was continued at -60° C. for 1 hour and then was added, dropwise, at -60° to -65° C., a solution of 11.1 g (0.11 mol) of triethylamine in 25 ml of dichloromethane. The cooling bath was removed, and when the reaction mixture had warmed to room temperature, 100 ml of water was added. The phases were separated, and the organic phase was washed with saturated sodium chloride solution, dried (Na₂ SO₄) and evaporated in vacuo. The residue was dissolved in 350 ml of diethyl ether, to which was added 40 ml of 2N hydrochloric acid. This mixture was stirred at room temperature overnight. The phases were separated and the ether phase was washed with water, followed saturated sodium chloride. The dried (Na₂ SO₄) ether phase was evaporated in vacuo to give 17 g of an orange-brown solid which was triturated under isopropyl ether. The solid was then recrystallized form ethanol, to give 5.58 g of 5-fluoro-3-methylthio-2-oxindole, m.p. 151.5°-152.5° C.

Analysis: Calcd for C₉ H₈ ONFS: C, 54.80; H, 4.09; N, 7.10%. Found: C, 54.74; H, 4.11; N, 7.11%.

A sample of the above 5-fluoro-3-methylthio-2-oxindole (986 mg, 5.0 mmol) was added to 2 teaspoonsful of Raney nickel under 50 ml of absolute ethanol, and then the reaction mixture was heated under reflux for 2 hours. The catalyst was removed by decantation and was washed with absolute ethanol. The combined ethanol solutions were evaporated in vacuo and the residue was dissolved in dichloromethane. The dichloromethane solution was dried (Na₂ SO₄) and evaporated in vacuo to give 475 mg of 5-fluoro-2-oxindole, m.p. 121°-134° C.

In analogous fashion, 4-trifluoromethylaniline was reacted with t-butyl hypochlorite, ethyl 2-(methylthio)acetate and triethylamine followed by reduction of the 3-thiomethyl-5-trifluoromethyl-2-oxindole thus obtained with Raney nickel, to give 5-trifluoromethyl-2-oxindole, m.p. 189.5°-190.5° C.

PREPARATION 12 5-Methoxy-2-oxindole

5-Methoxy-2-oxindole was prepared from 4-methoxyaniline in a manner similar to the procedure of Preparation 11, except that the initial chlorination step was carried out using a solution of chlorine gas in dichloromethane in place of t-butyl hypochlorite. The title product melted at 150.5°-151.5° C.

PREPARATION 13 6-Chloro-5-fluoro-2-oxindole

To 130 ml of toluene was added, with stirring, 24.0 g (0.165 mole) of 3-chloro-4-fluoroaniline and 13.5 ml (0.166 mole) of pyridine. The resulting solution was cooled to ca. 0° C. and 13.2 ml (0.166 mole) of 2-chloroacetyl chloride was added. The reaction mixture was stirred at room temperature for 5 hours and then it was extracted twice with 100 ml of 1N hydrochloric acid, followed by 100 ml of saturated sodium chloride solution. The resulting toluene solution was dried using magnesium sulfate, and then it was concentrated in vacuo to give 32.6 g (88% yield) of N-(2-chloroacetyl)-3-chloro-4-fluoroaniline.

A 26.63-g sample of the N-(2-chloroacetyl)-3-chloro-4-fluoroaniline was thoroughly mixed with 64 g of anhydrous aluminum chloride, and the mixture was heated at 210°-230° C. for 8.5 hours. The reaction mixture was then poured onto a mixture of ice and 1N hydrochloric acid, with stirring. Stirring was continued for 30 minutes, and then the solid was collected by filtration (22.0 g). The solid was dissolved in 1:1 ethyl acetate-hexane and chromatographed on 800 g of silica gel. Elution of the column, followed by evaporation of the fractions, produced 11.7 g of the N-(2-chloroacetyl)-3-chloro-4-fluoroaniline, followed by 3.0 g of 6-chloro-5-fluoro-2-oxindole. The latter material was recrystallized from toluene to give 1.70 g (7% yield) of the title compound, m.p. 196-206° C. Analysis by NMR spectroscopy indicated that the product was contaminated by some 4-chloro-5-fluoro-2-oxindole. A second crop weighing 0.8 g was obtained.

PREPARATION 14 6-Fluoro-5-methyl-2-oxindole

An intimate mixture of 11.62 g (57.6 mmol) of N-(2-chloroacetyl)-3-fluoro-4-methylaniline and 30.6 g (229.5 mmol) of anhydrous aluminum chloride was heated to 210°-220° C. After 4 hours, the reaction mixture was cooled and then added to 100 ml of 1N hydrochloric acid and 50 ml of ice. A tan solid formed, which was collected by filtration and recrystallized from aqueous ethanol. Three crops were obtained, weighing 4.49 g, 2.28 g and 1.0 g, respectively. The crop weighing 1.0 g was further recrystallized from water to give 280 mg of the title compound, m.p. 168.5°-171° C.

PREPARATION 15 6-Bromo-2-oxindole

To 9.4 g of sodium hydride was added 195 ml of dimethyl sulfoxide, followed by the dropwise addition of 22.37 ml of dimethyl malonate. At the end of the addition, the mixture was heated to 100° C. and maintained at that temperature for 40 minutes. At this point, 25 g of 1,4-dibromo-2-nitrobenzene was added all at once. The reaction mixture was maintained at 100° C. for 4 hours and then it was added to 1.0 liter of saturated ammonium chloride solution. The resulting mixture was extracted with ethyl acetate and the extracts were washed with ammonium chloride solution, water and saturated sodium chloride. The dried (MgSO₄) solution was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give 22.45 g of dimethyl 2-(4-bromo-2-nitrophenyl)malonate.

A solution of 17.4 g of dimethyl 2-(4-bromo-2-nitrophenyl)malonate and 4.6 g of lithium chloride in 150 ml of dimethyl sulfoxide was placed in an oil bath at 100° C. After 3 hours, the reaction mixture was cooled to room temperature and then it was poured into a mixture of 500 ml of ethyl acetate and 500 ml of saturated sodium chloride solution. The layers were separated and the aqueous layer was extracted with further ethyl acetate. The combined organic layers were washed with saturated sodium chloride solution, dried using sodium sulfate, and then evaporated in vacuo. The residue was chromatographed using silica gel as adsorbant and ethyl acetate-hexane mixture as eluant. This afforded 9.4 g of methyl 2-(4-bromo-2-nitrophenyl)acetate.

To a solution of 7.4 g of methyl 2-(4-bromo-2-nitrophenyl)acetate in 75 ml of acetic acid was added 6.1 g of iron powder. The reaction mixture was placed in an oil bath at 100° C. After 1 hour, the solvent was removed by evaporation in vacuo, and the residue was dissolved in 250 ml of ethyl acetate. The solution was filtered, washed with saturated sodium chloride solution, dried using sodium sulfate, decolorized using activated carbon, and evaporated in vacuo. This afforded 5.3 g of 6-bromo-2-oxindole as a white crystalline solid, m.p. 213°-214° C.

In like manner, starting with 1,4,5-trichloro-2-nitrobenzene, 5,6-dichloro-2-oxindole was prepared, m.p. 209°-210° C.

PREPARATION 16 6-Phenyl-2-oxindole

To 3.46 g. (0.072 mole) of sodium hydride was added 50 ml. of dimethyl sulfoxide followed by the dropwise addition of a solution of 8.2 ml. (0.072 mole) of dimethyl malonate in 10 ml. of dimethyl sulfoxide, with stirring. After completion of the addition, stirring was continued for 1 hour, and then a solution of 10 g. (0.036 mole) of 4-bromo-3-nitrodiphenyl in 50 ml. of dimethyl sulfoxide was added. The reaction mixture was heated to 100° C. for 1 hour, cooled, and poured onto a mixture of ice-water containing 5 g. of ammonium chloride. The mixture thus obtained was extracted with ethyl acetate, and the extracts were washed with sodium chloride solution and dried using magnesium sulfate. Evaporation in vacuo to give an oil, which was chromatographed using silica gel and then recrystallized from methanol to afford 6 g. of dimethyl 2-(3-nitro-4-diphenylyl)malonate, m.p. 82°-83° C.

A portion (5 g.) of the above nitro compound was reduced with hydrogen over a platinum catalyst, in a mixture of 50 ml. of tetrahydrofuran and 10 ml. of methanol, at a pressure of ca. 5 kg/cm², to give the corresponding amine. The latter compound was refluxed in ethanol for 16 hours, and then the product was recovered by solvent evaporation and recrystallized from methanol to give 1.1 g. of ethyl 6-phenyl-2-oxindole-1-carboxylate, m.p. 115°-117° C.

The above ethyl ester (1.0 g.) and 100 ml. of 6N hydrochloric acid was heated under reflux for 3 hours and then allowed to stand at room temperature for 3 days. The solid was collected by filtration and dried, to give 700 mg. of 6-phenyl-2-oxindole, m.p. 175°-176° C.

PREPARATION 17 5-Acetyl-2-oxindole

To 95 ml. of carbon disulfide was added 27 g. (0.202 mole) of aluminum chloride, followed by the dropwise addition of a solution of 3 ml. (0.042 mole) of acetyl chloride in 5 ml. of carbon disulfide, with stirring. Stirring was continued for 5 minutes and then 4.4 g. (0.033 mole) of 2-oxindole was added. The resulting mixture was heated under reflux for 4 hours and cooled. The carbon disulfide was removed by decantation and the residue was triturated under water and recovered by filtration. After drying, 3.2 g. of the title compound was obtained, m.p. 225°-227° C.

Reaction of 2-oxindole with benzoyl chloride and with 2-thenoyl chloride in the presence of aluminum chloride, substantially according to the above procedure, afforded the following compounds:

5-benzoyl-2-oxindole, m.p. 203°-205° C. (from CH₃ OH) and

5-(2-thenoyl)-2-oxindole, m.p. 211°-213° C. (from CH₃ CN).

PREPARATION 18

5-Bromo-2-oxindole, 5-nitro-2-oxindole and 5-amino-2-oxindole can be prepared as described in Beckett et al., Tetrahedron, 24, 6093 (1968). 5-Amino-2-oxindole can be acylated to give 5-alkanamido-2-oxindole and 5-benzamido-2-oxindole, using standard procedures.

5-n-Butyl-2-oxindole can be prepared by reaction of 5-n-butylisatin with hydrazine hydrate followed by sodium methoxide in ethanol, according to the procedure of Preparation 7. 5-n-Butylisatin can be prepared from 4-n-butylaniline by treatment with chloral hydrate and hydroxylamine, followed by cyclization with sulfuric acid, according to the procedure of Parts A and B of Preparation 9.

5-Ethoxy-2-oxindole can be prepared by conversion of 3-hydroxy-6-nitro-toluene into 3-ethoxy-6-nitro-toluene by standard methods (potassium carbonate and ethyl iodide in acetone), followed by conversion of the 3-ethoxy-6-nitrotoluene into 5-ethoxy-2-oxindole by the method described by Beckett et al., (Tetrahedron, 24, 6093 [1968]), for the conversion of 3-methoxy-6-nitro-toluene into 5-methoxy-2-oxindole. 5-n-Butoxy-2-oxindole can be prepared in like manner, but substituting n-butyl iodide for ethyl iodide.

5,6-Dimethoxy-2-oxindole can be prepared by the method of Walker, Journal of the American Chemical Society, 77, 3844 (1955).

7-Chloro-2-oxindole can be prepared by the method described in U.S. Pat. No. 3,882,236.

4-Thiomethyl-2-oxindole and 6-thiomethyl-2-oxindole can be prepared by the method described in U.S. Pat. No. 4,006,161. 5-n-Butylthio-2-oxindole can be prepared in like manner, but substituting 4-butylthioaniline for the 3-methylthioaniline.

5,6-Methylenedioxy-2-oxindole can be prepared by the method of McEvoy et al., Journal of Organic Chemistry, 38, 3350 (1973). 5,6-Ethylenedioxy-2-oxindole can be prepared in analogous fashion.

6-Fluoro-2-oxindole can be prepared according to Protiva et al., Collection of Czechoslovakian Chemical Communications, 44, 2108 (1979) and U.S. Pat. No. 4,160,032.

6-Trifluoromethyl-2-oxindole can be prepared according to Simet, Journal of Organic Chemistry, 28, 3580 (1963).

6-Methoxy-2-oxindole can be prepared according to Wieland et al., Chemische Berichte, 96, 253 (1963).

5-Cyclopropyl-2-oxindole and 5-cycloheptyl-2-oxindole can be prepared by reaction of 5-cyclopropylisatin and 5-cycloheptylisatin, respectively, with hydrazine hydrate followed by sodium methoxide in ethanol, according to the procedure of Preparation 7. 5-Cyclopropylisatin and 5-cycloheptylisatin can be prepared from 4-cyclopropylaniline and 4-cycloheptylaniline, respectively, by treatment with chloral hydrate and hydroxylamine, followed by cyclization with sulfuric acid, according to Parts A and B of Preparation 9. 

I claim:
 1. A 2-oxindole-1-carboxamide compound of the formula ##STR18## and the pharmaceutically-acceptable salts thereof; wherein X is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons, trifluoromethyl, alkylsulfinyl having 1 to 4 carbons, alkylsulfonyl having 1 to 4 carbons, nitro, phenyl, alkanoyl having 2 to 4 carbons, benzoyl, thenoyl, alkanamido having 2 to 4 carbons, benzamido and N,N-dialkylsulfamoyl having 1 to 3 carbons in each of said alkyls; and Y is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons and trifluoromethyl;or X and Y when taken together are a 4,5-, 5,6- or 6,7-methylenedioxy group or a 4,5-, 5,6- or 6,7-ethylenedioxy group; or X and Y when taken together and when attached to adjacent carbon atoms form a divalent radical Z, wherein Z is selected from the group consisting of ##STR19## wherein W is oxygen or sulfur; R¹ is selected from the group consisting of alkyl having 1 to 6 carbons, cycloalkyl having 3 to 7 carbons, cycloalkenyl having 4 to 7 carbons, phenyl, substituted phenyl, phenylalkyl having 1 to 3 carbons in said alkyl, (substituted phenyl)alkyl having 1 to 3 carbons in said alkyl, phenoxyalkyl having 1 to 3 carbons in said alkyl, (substituted phenoxy)alkyl having 1 to 3 carbons in said alkyl, (thiophenoxy)alkyl having 1 to 3 carbons in said alkyl, naphthyl, bicyclo[2.2.1]heptan-2-yl, bicyclo[2.2.1]hept-5-en-2-yl and --(CH₂)_(n) --Q--R°; wherein the substituent on said substituted phenyl, said (substituted phenyl)alkyl and said (substituted phenoxy)alkyl is selected from the group consisting of fluoro, chloro, bromo, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl; n is zero, 1 or 2; Q is a divalent radical derived from a compound selected from the group consisting of furan, thiophene, pyrrole, pyrazole, imidazole, thiazole, isothiazole, oxazole, isoxazole, 1,2,3-thiadiazole, 1,3,4-thiadiazole, 1,2,5-thiadiazole, tetrahydrofuran, tetrahydrothiophene, tetrahydropyran, tetrahydrothiopyran, pyridine, pyrimidine, pyrazine, benzo[b]furan and benzo[b]thiophene; and R° is hydrogen or alkyl having 1 to 3 carbons. and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl and a group of the formula ##STR20## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.
 2. A compound according to claim 1, whereinX is at the 5-position or the 6-position and it is selected from the group consisting of hydrogen, fluoro, chloro, bromo and trifluoromethyl; and Y is hydrogen; R¹ is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, furyl, thienyl, phenylalkyl having 1 to 3 carbons in said alkyl, furylmethyl, thienylmethyl and trifluoromethyl; and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons and a group of the formula ##STR21## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.
 3. A compound according to claim 1, wherein X and Y are each selected from the group consisting of hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl and 6-trifluoromethyl.
 4. A compound according to claim 3, wherein R¹ is selected from the group consisting of benzyl, 2-furyl, 2-thienyl, (2-furyl)methyl and (2-thienyl)methyl.
 5. A compound according to claim 4, wherein Y is hydrogen.
 6. A compound according to claim 5, wherein R² is selected from the group consisting of isopropyl and t-butyl.
 7. A compound according to claim 6, wherein X is 5-chloro or 6-chloro.
 8. The compound according to claim 7, wherein X is 5-chloro, R¹ is 2-furyl and R² is t-butyl.
 9. The compound according to claim 7, wherein X is 6-chloro, R¹ is 2-thienyl and R² is t-butyl
 10. A compound according to claim 6, wherein X is 5-fluoro.
 11. The compound according to claim 10, wherein R¹ is 2-furyl and R² is t-butyl.
 12. A compound according to claim 5, wherein R² is said ##STR22##
 13. The compound according to claim 12, wherein X is hydrogen, R¹ is 2-thienyl and R² is 4-methoxyphenyl.
 14. The compound according to claim 12, wherein X is hydrogen, R¹ is 2-furyl and R² is 2,4-difluorophenyl.
 15. A compound according to claim 4, wherein X and Y are each selected from the group consisting of 5-fluoro, 6-fluoro, 5-chloro and 6-chloro.
 16. A compound according to claim 15, wherein R² is selected from the group consisting of isopropyl and t-butyl.
 17. A method of eliciting an analgesic response in a mammalian subject, which comprises administering to said subject an analgesic response eliciting amount of a 2-oxindole-1-carboxamide compound of the formula ##STR23## or a pharmaceutically-acceptable salt thereof; whereinX is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons, trifluoromethyl, alkylsulfinyl having 1 to 4 carbons, alkylsulfonyl having 1 to 4 carbons, nitro, phenyl, alkanoyl having 2 to 4 carbons, benzoyl, thenoyl, alkanamido having 2 to 4 carbons, benzamido and N,N-dialkylsulfamoyl having 1 to 3 carbons in each of said alkyls; and Y is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons and trifluoromethyl; or X and Y when taken together are a 4,5-, 5,6-or 6,7-methylenedioxy group or a 4,5-, 5,6- or 6,7-ethylenedioxy group; or X and Y when taken together and when attached to adjacent carbon atoms form a divalent radical Z, wherein Z is selected from the group consisting of ##STR24## wherein W is oxygen or sulfur; R¹ is selected from the group consisting of alkyl having 1 to 6 carbons, cycloalkyl having 3 to 7 carbons, cycloalkenyl having 4 to 7 carbons, phenyl, substituted phenyl, phenylalkyl having 1 to 3 carbons in said alkyl, (substituted phenyl)alkyl having 1 to 3 carbons in said alkyl, phenoxyalkyl having 1 to 3 carbons in said alkyl, (substituted phenoxy)alkyl having 1 to 3 carbons in said alkyl, (thiophenoxy)alkyl having 1 to 3 carbons in said alkyl, naphthyl, bicyclo[2.2.1]heptan-2-yl, bicyclo[2.2.1]hept-5-en-2-yl and --(CH₂)_(n) --Q--R°; wherein the substituent on said substituted phenyl, said (substituted phenyl)alkyl and said (substituted phenoxy)alkyl is selected from the group consisting of fluoro, chloro, bromo, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl; n is zero, 1 or 2; Q is a divalent radical derived from a compound selected from the group consisting of furan, thiophene, pyrrole, pyrazole, imidazole, thiazole, isothiazole, oxazole, isoxazole, 1,2,3-thiadiazole, 1,3,4-thiadiazole, 1,2,5-thiadiazole, tetrahydrofuran, tetrahydrothiophene, tetrahydropyran, tetrahydrothiopyran, pyridine, pyrimidine, pyrazine, benzo[b]furan and benzo[b]thiophene; and R° is hydrogen or alkyl having 1 to 3 carbons; and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl and a group of the formula ##STR25## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.
 18. The method according to claim 17, whereinX is at the 5-position or the 6-position and it is selected from the group consisting of hydrogen, fluoro, chloro, bromo and trifluoromethyl; and Y is hydrogen; R¹ is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, furyl, thienyl, phenylalkyl having 1 to 3 carbons in said alkyl, furylmethyl, thienylmethyl and trifluoromethyl; and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons and a group of the formula ##STR26## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.
 19. The method according to claim 17, wherein X and Y are each selected from the group consisting of hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl and 6-trifluoromethyl.
 20. The method according to claim 19, wherein R¹ is selected from the group consisting of benzyl, 2-furyl, 2-thienyl, (2-furyl)methyl and (2-thienyl)methyl.
 21. The method according to claim 20, wherein Y is hydrogen.
 22. The method according to claim 21, wherein R² is selected from the group consisting of isopropyl and t-butyl.
 23. The method according to claim 22, wherein X is 5-chloro or 6-chloro.
 24. The method according to claim 23, wherein X is 5-chloro, R¹ is 2-furyl and R² is t-butyl.
 25. The method according to claim 23, wherein X is 6-chloro, R¹ is 2-thienyl and R² is t-butyl.
 26. The method according to claim 22, wherein X is 5-fluoro.
 27. The method according to claim 26, wherein R¹ is 2-furyl and R² is t-butyl.
 28. The method according to claim 21, wherein R² is said ##STR27##
 29. The method according to claim 28, wherein X is hydrogen, R¹ is 2-thienyl and R² is 4-methoxyphenyl.
 30. The method according to claim 28, wherein X is hydrogen, R¹ is 2-furyl and R² is 2,4-difluorophenyl.
 31. The method according to claim 20, wherein X and Y are each selected from the group consisting of 5-fluoro, 6-fluoro, 5-chloro and 6-chloro.
 32. The method according to claim 31, wherein R² is selected from the group consisting of isopropyl and t-butyl.
 33. A method of treating an inflammatory disease in a mammalian subject, which comprises administering to said mammalian subject an inflammatory disease treating amount of a 2-oxindole-1-carboxamide compound of the formula ##STR28## or a pharmaceutically-acceptable salt thereof; wherein X is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons, trifluoromethyl, alkylsulfinyl having 1 to 4 carbons, alkylsulfonyl having 1 to 4 carbons, nitro, phenyl, alkanoyl having 2 to 4 carbons, benzoyl, thenoyl, alkanamido having 2 to 4 carbons, benzamido and N,N-dialkylsulfamoyl having 1 to 3 carbons in each of said alkyls; and Y is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons and trifluoromethyl;or X and Y when taken together are a 4,5-, 5,6-or 6,7-methylenedioxy group or a 4,5-, 5,6- or 6,7-ethylenedioxy group; or X and Y when taken together and when attached to adjacent carbon atoms form a divalent radical Z, wherein Z is selected from the group consisting of ##STR29## wherein W is oxygen or sulfur; R¹ is selected from the group consisting of alkyl having 1 to 6 carbons, cycloalkyl having 3 to 7 carbons, cycloalkenyl having 4 to 7 carbons, phenyl, substituted phenyl, phenylalkyl having 1 to 3 carbons in said alkyl, (substituted phenyl)alkyl having 1 to 3 carbons in said alkyl, phenoxyalkyl having 1 to 3 carbons in said alkyl, (substituted phenoxy)alkyl having 1 to 3 carbons in said alkyl, (thiophenoxy)alkyl having 1 to 3 carbons in said alkyl, naphthyl, bicyclo[2.2.1]heptan-2-yl, bicyclo[2.2.1]hept-5-en-2-yl and --(CH₂)_(n) --Q--R°; wherein the substituent on said substituted phenyl, said (substituted phenyl)alkyl and said (substituted phenoxy)alkyl is selected from the group consisting of fluoro, chloro, bromo, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl; n is zero, 1 or 2; Q is a divalent radical derived from a compound selected from the group consisting of furan, thiophene, pyrrole, pyrazole, imidazole, thiazole, isothiazole, oxazole, isoxazole, 1,2,3-thiadiazole, 1,3,4-thiadiazole, 1,2,5-thiadiazole, tetrahydrofuran, tetrahydrothiophene, tetrahydropyran, tetrahydrothiopyran, pyridine, pyrimidine, pyrazine, benzo[b]furan and benzo[b]thiophene; and R° is hydrogen or alkyl having 1 to 3 carbons; and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl and a group of the formula ##STR30## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.
 34. The method according to claim 33, whereinX is at the 5-position or the 6-position and it is selected from the group consisting of hydrogen, fluoro, chloro, bromo and trifluoromethyl; and Y is hydrogen; R¹ is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, furyl, thienyl, phenylalkyl having 1 to 3 carbons in said alkyl, furylmethyl, thienylmethyl and trifluoromethyl; and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons and a group of the formula ##STR31## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.
 35. The method according to claim 33, wherein X and Y are each selected from the group consisting of hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl and 6-trifluoromethyl.
 36. The method according to claim 35, wherein R¹ is selected from the group consisting of benzyl, 2-furyl, 2-thienyl, (2-furyl)methyl and (2-thienyl)methyl.
 37. The method according to claim 36, wherein Y is hydrogen.
 38. The method according to claim 37, wherein R² is selected from the group consisting of isopropyl and t-butyl.
 39. The method according to claim 38, wherein X is 5-chloro or 6-chloro.
 40. The method according to claim 39, wherein X is 5-chloro, R¹ is 2-furyl and R² is t-butyl.
 41. The method according to claim 39, wherein X is 6-chloro, R¹ is 2-thienyl and R² is t-butyl.
 42. The method according to claim 38, wherein X is 5-fluoro.
 43. The method according to claim 42, wherein R¹ is 2-furyl and R² is t-butyl.
 44. The method according to claim 37, wherein R² is said ##STR32##
 45. The method according to claim 44, wherein X is hydrogen, R¹ is 2-thienyl and R² is 4-methoxyphenyl.
 46. The method according to claim 44, wherein X is hydrogen, R¹ is 2-furyl and R² is 2,4-difluorophenyl.
 47. The method according to claim 36, wherein X and Y are each selected from the group consisting of 5-fluoro, 6-fluoro, 5-chloro and 6-chloro.
 48. The method according to claim 47, wherein R² is selected from the group consisting of isopropyl and t-butyl.
 49. A pharmaceutical composition, useful as an analgesic and antiinflammatory agent in a mammalian subject, which comprises a pharmaceutically-acceptable carrier and an analgesic response eliciting or inflammatory disease treating amount of a 2-oxindole-1-carboxamide compound according to claim 1, and wherein the weight ratio of the pharmaceutically-acceptable carrier to the 2-oxindole-1-carboxamide compound is in the range from 1:4 to 4:1.
 50. A compound of the formula ##STR33## wherein X and Y are each selected from the group consisting of hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl and 6-trifluoromethyl, provided that X and Y are not both hydrogen;and R² is selected from the group consisting of alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl and a group of the formula ##STR34## wherein R³ and R⁴ are each selected from the group consisting of hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons and trifluoromethyl.
 51. A compound according to claim 50, wherein Y is hydrogen.
 52. A compound according to claim 51, wherein R² is selected from the group consisting of isopropyl and t-butyl.
 53. A compound according to claim 52, wherein X is 5-chloro or 6-chloro.
 54. The compound according to claim 53, wherein X is 5-chloro and R² is t-butyl.
 55. The compound according to claim 53, wherein X is 6-chloro and R² is t-butyl.
 56. A compound according to claim 52, wherein X is 5-fluoro.
 57. The compound according to claim 56, wherein R² is t-butyl. 